Results 301 to 310 of about 580,024 (350)

Mechanism of Antitumor Activity of Tumor Necrosis Factor   With Hyperthermia in a Tumor Necrosis Factor  -Resistant Tumor

JNCI Journal of the National Cancer Institute, 1990
Cells from a radiation-induced fibrosarcoma (RIF-1) are exceedingly resistant to tumor necrosis factor alpha (TNF-alpha) in vitro. We tested whether the addition of mild hyperthermia (42.5 degrees C, 30 minutes) could enhance TNF-alpha activity against RIF-1 tumors growing in syngeneic hosts (C3H mice). TNF-alpha was administered intratumorally.
J M, Srinivasan, L F, Fajardo, G M, Hahn
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Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis

JCR: Journal of Clinical Rheumatology, 2010
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of ...
Clementine, Rochelle Robicheaux, Lyman, Justin, Zakem, Jerald, Mallepalli, Jyothi, Lindsey, Stephen, Quinet, Robert   +5 more
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Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis

American Journal of Perinatology, 1997
Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A., Satar M., Çetíner S., Yaman A.   +3 more
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Tumor Necrosis Factor Alpha Production by Oral Leukocytes: Influence of Tumor Necrosis Factor Genotype

Journal of Periodontology, 1998
Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
G M, Galbraith, R B, Steed, J J, Sanders, J P, Pandey   +3 more
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Bioassay for Tumor Necrosis Factors-alpha and -beta

Molecular Biotechnology, 2000
Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine.
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Four epitopes on tumor necrosis factor-alpha defined by murine anti-tumor necrosis factor-alpha monoclonal antibodies

Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim, R, Béliard, J J, Huart, D, Bourel   +3 more
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Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995
The occurrence of acute hepatic failure during systemic inflammatory response syndrome (SIRS) is related to the extent of hepatocyte (HC) damage and cell death resulting from necrosis or apoptosis. We hypothesized that proinflammatory mediators such as lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) can, either directly or ...
J H, Wang, H P, Redmond, R W, Watson, D, Bouchier-Hayes   +3 more
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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists

American Journal of Therapeutics, 2013
The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan, Augustine M, Manadan, Winston, Sequiera, Joel A, Block   +3 more
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Engineering a Synthetic Ligand for Tumor Necrosis Factor–Alpha

Bioconjugate Chemistry, 2011
One approach to prepare protein binding ligands is to join two low-affinity ligands that bind different sites on the target protein to create a high-affinity bivalent ligand. This typically requires some knowledge of the ligand binding site and requires exquisite orientation of the ligands in order to achieve maximum binding affinity. Here, we explored
Nidhi, Gupta, Paul E, Belcher, Stephen Albert, Johnston, Chris W, Diehnelt   +3 more
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Nano anti-tumor necrosis factor-alpha based potentiometric sensor for tumor necrosis factor-alpha detection

Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan, Özkütük, Ebru Birlik, Ünlüer, Özlem Biçen, Uğurag, Deniz, Ersöz, Arzu   +4 more
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