Results 331 to 340 of about 666,626 (377)

Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury.

Stroke, 1997
BACKGROUND AND PURPOSE Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine that rapidly upregulates in the brain after injury. The present study was designed to explore the pathophysiological significance of brain TNF-alpha in the ischemic ...
F. Barone, B. Arvin, R. F. White, A. Miller, C. Webb, R. Willette, P. G. Lysko, G. Feuerstein   +7 more
semanticscholar   +1 more source

Bioassay for Tumor Necrosis Factors-alpha and -beta

Molecular Biotechnology, 2000
Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine.
openaire   +3 more sources

Production of Tumor Necrosis Factor-Alpha in Patients on Hemodiafiltration

Nephron, 1992
The systemic production of tumor necrosis factor (TNF)-alpha was evaluated in uremic patients before and after hemodiafiltration (HDF) and paired filtration dialysis (PFD) and in the interdialytic period. Both HDF and PFD were performed using polysulfone dialyzers with either standard or ultrapure dialysis fluid.
Tetta C, Fidelio T, Licata C, Iacono L, Sancipriano G, BIANCONE, Luigi, Ragni R, SEGOLONI, Giuseppe, CAMUSSI, Giovanni   +8 more
openaire   +4 more sources

Tumor Necrosis Factor α and Toxicology

Critical Reviews in Toxicology, 1999
The molecular cloning of a group of proteins, collectively referred to as cytokines, and including interleukins, chemokines, growth factors, colony stimulating factors, and tumor necrosis factors, has allowed for the increased understanding of the mechanisms for many disease processes as well as provided strategies for the development of novel ...
Michael I. Luster, Randle M. Gallucci, Petia P. Simeonova, Joanna M. Matheson   +3 more
openaire   +3 more sources

Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995
The occurrence of acute hepatic failure during systemic inflammatory response syndrome (SIRS) is related to the extent of hepatocyte (HC) damage and cell death resulting from necrosis or apoptosis. We hypothesized that proinflammatory mediators such as lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) can, either directly or ...
Henry Paul Redmond, Jiang Huai Wang, R. W. G. Watson, David Bouchier-Hayes   +3 more
openaire   +3 more sources

Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides.

Arthritis & Rheumatism, 2001
OBJECTIVE To review the occurrence of neurologic events suggestive of demyelination during anti-tumor necrosis factor alpha (anti-TNFalpha) therapy for inflammatory arthritides.
N. Mohan, Evelyne T. Edwards, T. Cupps, P. Oliverio, G. Sandberg, H. Crayton, J. Richert, J. Siegel   +7 more
semanticscholar   +1 more source

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

American Journal of Respiratory Cell and Molecular Biology, 1994
Asthma is characterized by the presence of an inflammatory cell infiltrate in the bronchial mucosa consisting of activated mast cells, eosinophils, and T cells.
P. Bradding, J. Roberts, K. Britten, S. Montefort, R. Djukanović, R. Mueller, C. Heusser, P. Howarth, S. Holgate   +8 more
semanticscholar   +1 more source

Tumor necrosis factor-alpha (TNF-α) in pleural fluids

Tubercle and Lung Disease, 1995
Our study was undertaken to investigate the role of tumor necrosis factor-alpha (TNF-alpha) at the site of disease activity in tuberculous pleuritis (TP). Concentrations of TNF-alpha were measured directly by radioimmunoassay (RIA) in the pleural fluid (PF) and plasma (P) of patients with TP (n = 14), malignant effusions (n = 18) and transudates (n = 7)
Gürsel, GÜL, Ekim, N, Samurkaşoğlu, B, Elbeg, S, Gökçora, N   +4 more
openaire   +4 more sources

Mechanism of Antitumor Activity of Tumor Necrosis Factor   With Hyperthermia in a Tumor Necrosis Factor  -Resistant Tumor [PDF]

JNCI Journal of the National Cancer Institute, 1990
Cells from a radiation-induced fibrosarcoma (RIF-1) are exceedingly resistant to tumor necrosis factor alpha (TNF-alpha) in vitro. We tested whether the addition of mild hyperthermia (42.5 degrees C, 30 minutes) could enhance TNF-alpha activity against RIF-1 tumors growing in syngeneic hosts (C3H mice). TNF-alpha was administered intratumorally.
Janaki M. Srinivasan, George M. Hahn, Luis F. Fajardo   +2 more
openaire   +2 more sources

The regulation of circadian clock by tumor necrosis factor alpha

Cytokine & Growth Factor Reviews, 2019
All organisms display circadian rhythms which are under the control of the circadian clock located in the hypothalamus at the suprachiasmatic nucleus, (SCN). The circadian rhythms allow individuals to adjust their physiological activities and daily behavior for the diurnal changes in the living environment. To achieve these, all metabolic processes are
Mustafa Gökhan Ertosun, Osman Nidai Ozes, Gamze Kocak   +2 more
openaire   +3 more sources