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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists
American Journal of Therapeutics, 2013The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Winston Sequiera +3 more
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Engineering a Synthetic Ligand for Tumor Necrosis Factor–Alpha
Bioconjugate Chemistry, 2011One approach to prepare protein binding ligands is to join two low-affinity ligands that bind different sites on the target protein to create a high-affinity bivalent ligand. This typically requires some knowledge of the ligand binding site and requires exquisite orientation of the ligands in order to achieve maximum binding affinity. Here, we explored
Stephen Albert Johnston +3 more
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Induction of apoptosis in chondrocytes by tumor necrosis factor‐alpha
Journal of Orthopaedic Research, 2001AbstractTumor necrosis factor alpha (TNF‐α) induces apoptosis in a number of cell types and plays an essential role in bone remodeling, both stimulating the proliferation of osteoblasts and activating osteoclasts. During endochondral ossification, apoptosis of chondrocytes occurs concurrently with new bone formation and the resorption and replacement ...
Thomas A. Einhorn +4 more
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The molecular action of tumor necrosis factor-α
European Journal of Biochemistry, 1991Tumor necrosis factor‐α (TNF‐α) is a polypeptide hormone newly synthesized by different cell types upon stimulation with endotoxin, inflammatory mediators (C5a anaphylatoxin), or cytokines such as interleukin‐1 and, in an autocrine manner, TNF itself.
CAMUSSI, Giovanni +3 more
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TUMOR NECROSIS FACTOR-α GENE AND CEREBRAL ANEURYSMS
Neurosurgery, 2007The pathogenesis of intracranial aneurysms is still uncertain. In addition to atherosclerosis, immunological factors may play a role in the disease. Recent studies have suggested that tumor necrosis factor-alpha (TNF-alpha), one of the main proinflammatory cytokines, may play a key role in the formation and rupture of cerebral aneurysms. The purpose of
FONTANELLA, Marco Maria +9 more
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Journal of Clinical Oncology, 1992
PURPOSE To determine the toxicity and the therapeutic efficacy of the combination of the recombinant tumor necrosis factor alpha (rTNF alpha), recombinant interferon gamma (rIFN-gamma), and melphalan, we designed a protocol using isolation limb perfusion
D. Liénard +4 more
semanticscholar +1 more source
PURPOSE To determine the toxicity and the therapeutic efficacy of the combination of the recombinant tumor necrosis factor alpha (rTNF alpha), recombinant interferon gamma (rIFN-gamma), and melphalan, we designed a protocol using isolation limb perfusion
D. Liénard +4 more
semanticscholar +1 more source
Cytotoxic mechanism of tumor necrosis factor‐α
The FASEB Journal, 1990Many intracellular pathways are set in motion by the binding of tumor necrosis factor (TNF) to its cell surface receptor. Major steps in the TNF-mediated cytotoxicity cascade include G protein-coupled activation of phospholipases, generation of free radicals, and damage to nuclear DNA by endonucleases.
James W Larrick, Susan Wright
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[Tumor necrosis factor alpha. Biological aspects].
Giornale italiano di chemioterapia, 1989Human Tumor Necrosis Factor-alpha (TNF-alpha) is a multifaceted cytokine mainly produced by activated monocytes or macrophages. Several recent studies have shown that TNF-alpha can exert a variety of in vitro and in vivo effects including: modulation of normal and malignant haemopoiesis, antineoplastic activity, activation of neutrophils, induction of ...
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Piezoelectric biosensor for the determination of Tumor Necrosis Factor Alpha
Talanta, 2018Tumor Necrosis Factor Alpha (TNFα) is an important marker of inflammatory processes in human body. In the current healthcare, determination of TNFα blood or plasma level is done by Enzyme Linked Immuno-Sorbent Assay (ELISA) as a primary choice method. Piezoelectric immunosensors are analytical platform recording affinity interactions on their surface ...
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