Results 341 to 350 of about 729,544 (396)
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Role of tumor necrosis factor alpha in asthma
Immunology and Allergy Clinics of North America, 2004Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such
Babu, K. Suresh +2 more
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Tumor necrosis factor alpha in mycobacterial infection
Seminars in Immunology, 2014Tumor necrosis factor alpha (TNF-α) is a critical immune mediator in protection against and pathology of tuberculosis (TB). TNF-α had been found to be associated with TB when it was originally identified as cachexin and until today TB research continues to unveil novel roles of this cytokine of highest relevance for the disease process and for novel ...
Anca, Dorhoi, Stefan H E, Kaufmann
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Production of Tumor Necrosis Factor Alpha and Hemodialysis
Nephron, 1993The production of TNF alpha by peripheral blood mononuclear cells (PBMC) was determined in 18 hemodialysis (HD) patients. Blood was taken from each patient before and after an HD treatment. Both pre- and post-HD PBMC produced significantly more TNF alpha than controls (TNF alpha units/ml; mean +/- SEM; controls 3.1 +/- 0.7; pre-HD 9.7 +/- 3.9; post-HD ...
C, Macdonald +3 more
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[Tumor necrosis factor alpha].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1992TNF-alpha (Cachectin) is a cytokine (tissue hormone) synthesized and secreted as a trimeric polypeptide; major producers are the cells of the RES after stimulation, e.g. by endotoxin. Its synthesis is strictly regulated. TNF elicits a great number of cell-specific responses. IL-1 and probably additional mediators cooperate in these effects.
C S, Rock, S F, Lowry
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Tumor Necrosis Factor α and Toxicology
Critical Reviews in Toxicology, 1999The molecular cloning of a group of proteins, collectively referred to as cytokines, and including interleukins, chemokines, growth factors, colony stimulating factors, and tumor necrosis factors, has allowed for the increased understanding of the mechanisms for many disease processes as well as provided strategies for the development of novel ...
M I, Luster +3 more
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JNCI Journal of the National Cancer Institute, 1990
Cells from a radiation-induced fibrosarcoma (RIF-1) are exceedingly resistant to tumor necrosis factor alpha (TNF-alpha) in vitro. We tested whether the addition of mild hyperthermia (42.5 degrees C, 30 minutes) could enhance TNF-alpha activity against RIF-1 tumors growing in syngeneic hosts (C3H mice). TNF-alpha was administered intratumorally.
J M, Srinivasan, L F, Fajardo, G M, Hahn
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Cells from a radiation-induced fibrosarcoma (RIF-1) are exceedingly resistant to tumor necrosis factor alpha (TNF-alpha) in vitro. We tested whether the addition of mild hyperthermia (42.5 degrees C, 30 minutes) could enhance TNF-alpha activity against RIF-1 tumors growing in syngeneic hosts (C3H mice). TNF-alpha was administered intratumorally.
J M, Srinivasan, L F, Fajardo, G M, Hahn
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Bioassay for Tumor Necrosis Factors-alpha and -beta
Molecular Biotechnology, 2000Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine.
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Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis
American Journal of Perinatology, 1997Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A. +3 more
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Journal of Periodontology, 1998
Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
G M, Galbraith +3 more
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Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
G M, Galbraith +3 more
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Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim +3 more
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Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim +3 more
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