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Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995The occurrence of acute hepatic failure during systemic inflammatory response syndrome (SIRS) is related to the extent of hepatocyte (HC) damage and cell death resulting from necrosis or apoptosis. We hypothesized that proinflammatory mediators such as lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) can, either directly or ...
J H, Wang +3 more
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The regulation of circadian clock by tumor necrosis factor alpha
Cytokine & Growth Factor Reviews, 2019All organisms display circadian rhythms which are under the control of the circadian clock located in the hypothalamus at the suprachiasmatic nucleus, (SCN). The circadian rhythms allow individuals to adjust their physiological activities and daily behavior for the diurnal changes in the living environment. To achieve these, all metabolic processes are
Mustafa Gokhan, Ertosun +2 more
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Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis
JCR: Journal of Clinical Rheumatology, 2010Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of ...
Clementine, Rochelle Robicheaux +5 more
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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists
American Journal of Therapeutics, 2013The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan +3 more
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Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Cardiodepression by tumor necrosis factor-alpha.
European cytokine network, 1999Cardiodepressant effects of tumor necrosis factor-alpha (TNF-alpha have been documented in numerous experimental settings in vivo and in vitro. In vivo administration of TNF-alpha mimicks the cardiovascular pattern of sepsis including septic cardiomyopathy.
U, Müller-Werdan +2 more
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Production of Tumor Necrosis Factor-Alpha in Patients on Hemodiafiltration
Nephron, 1992The systemic production of tumor necrosis factor (TNF)-alpha was evaluated in uremic patients before and after hemodiafiltration (HDF) and paired filtration dialysis (PFD) and in the interdialytic period. Both HDF and PFD were performed using polysulfone dialyzers with either standard or ultrapure dialysis fluid.
Tetta C +8 more
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Science, 1993G. Hotamisligil +2 more
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[Tumor necrosis factor alpha. Biological aspects].
Giornale italiano di chemioterapia, 1989Human Tumor Necrosis Factor-alpha (TNF-alpha) is a multifaceted cytokine mainly produced by activated monocytes or macrophages. Several recent studies have shown that TNF-alpha can exert a variety of in vitro and in vivo effects including: modulation of normal and malignant haemopoiesis, antineoplastic activity, activation of neutrophils, induction of ...
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