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A multi-targeted approach to suppress tumor-promoting inflammation [PDF]
, 2015 Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts ...Abbas K. Samadi, Abboud, Abraham, Abu-Eid, Addison, Administration. USFaD, Afaq, Aggarwal, Aggarwal, Aggarwal, Aggarwal, Aggarwal, Aggarwal, Ahmad, Ahmed, Ahuja, Akiyama, Aktas, Alan Bilsland, Alexandros G. Georgakilas, Ali, Allred, Almeida, Almeida, Almeida, Altamemi, Amedeo Amedei, Amin, Amiri, Amr Amin, Anand, Andreasson, Anttila, Anupam Bishayee, Aravindaram, Arber, Arbiser, Arumugam, Asangani, Asare, Asaumi, Asfar S. Azmi, Ashkenazi, Askling, Axelsson, Babu, Bach, Bachmeier, Baek, Bal L. Lokeshwar, Balkwill, Balkwill, Balkwill, Balkwill, Balkwill, Bandi, Banerjee, Banerjee, Baniyash, Bansal, Bao, Baoping, Barlow, Baumgarten, Bazzoni, Beck, Beg, Bell, Bellacosa, Bellocq, Ben-Neriah, Benetou, Bentz, Berasain, Berletch, Bernard, Bertagnolli, Bertazza, Beyne-Rauzy, Bhattacharyya, Bhaumik, Bielecki, Bifulco, Billottet, Binder, Bishayee, Bishayee, Bishayee, Bishayee, Bishayee, Bishayee, Bishayee, Biswas, Biswas, Bluestone, Bobanga, Bocca, Bogatcheva, Boldin, Bonci, Bongartz, Bonvissuto, Boosani, Borghese, Borm, Borsig, Brendan Grue, Brest, Brindicci, Brindicci, Brown, Bucala, Bureyko, Burn, Burn, Burns, Buttari, Caamano, Cai, Calandra, Calandra, Calin, Calin, Carolina Panis, Carrasco, Carroll, Cassileth, Cassinelli, Cerella, Chainani-Wu, Chakrabarti, Chandra S. Boosani, Chang, Chang, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Cho, Cho, Choe, Choi, Choudhary, Chow, Chu, Chun, Chung, Cichocki, Ciesek, Ciruelos Gil, Clark, Cobb, Coffer, Colotta, Connelly, Conroy, Costinean, Cottart, Coussens, Cruz-Correa, Cui, Cui, Dahiya, Dai, Das, Das, De Ledinghen, de Nigris, DeClerck, Deepak Poudyal, Degterev, Dejardin, Delhalle, Demaria, DeNardo, Deng, deVere White, Dhawan, Dhillon, Di, Di Tomo, Diana M. Stafforini, DiDonato, Dipita Bhakta, Disis, Doi, Dolcet, Dong, Donovan, Dorsam, Drenckhan, Dryden, du Rieu, Dubois, Duda, Eck, EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), Eigner, Eis, El-Rayes, Elena Niccolai, Ellie, Erasalo, Esquela-Kerscher, Etminan, Fajardo, Falchetti, Farghali, Faria, Fasanaro, Faurschou, Feinstein, Feldmann, Feller, Feng, Ferenc, Fernando, Flores, Fosslien, Fotsis, Fouad, Fouad, Franciszkiewicz, Freedman, Friberg, Fuggetta, Fujisawa, Fujita, Gaballah, Gagliano, Ganiger, Ganster, Gantier, Gao, Garcea, Garcea, Garufi, Gatz, Georgakilas, Gescher, Ghaemi, Gharib, Giannakakis, Giese, Gil, Giliano, Ginestier, Giovannucci, Gironella, Goel, Goldmann, Gomez, Gong, Goo, Goto, Goulet, Gowda, Greathouse, Greenhough, Greten, Grieb, Grivennikov, Grivennikov, Grivennikov, Grosch, Gu, Gunjan Guha, Guo, Guo, Guo, Guo, Gupta, Gupta, H.M.C. Shantha Kumara, H.P. Vasantha Rupasinghe, Ha, Haas, Haasch, Hadad, Haddad, Hajri, Hamed, Han, Hanahan, Hansel, Hara, Harikumar, Hasegawa, Hasima, Hattermann, Havell, Hayden, He, He, He, He, He, Herrera, Hidaka, Hill, Hiromasa Fujii, Hofmann, Hojo, Houede, Howell, Howells, Howells, Hsu, Hu, Huang, Huang, Huang, Huang, Huang, Huang, Hushmendy, Hussain, Hussain, Hussain, Hussain, Hussain, Hussain, Hwang, Hwang, Hwang, Iliopoulos, Iliopoulos, Inoue, Institute NC, Ioannou, Ireson, Ireson, Isbrucker, Ishigami, Ishizaki, Itzkowitz, Iwasaki, Izzotti, Jadeski, Jagadeesh, Jang, Jendrossek, Jeon, Jeong, Jha, Ji, Ji, Jiang, Jiang, Jiang, Jiang, Jiao, Jin, Jin, Jin, Johnson, Johnson, Jones, Jones, Jonker, Ju, Juarez, Jung, Junker, Kane, Kanya Honoki, Kanzler, Kapil Mehta, Karadayi, Karar, Karin, Karin, Karius, Katia Aquilano, Keystone, Khatami, Khaw, Khor, Kim, Kim, Kim, Kim, Kim, Kim, Kim, Kim, Kirsh, Kitajima, Kitano, Klein, Klotz, Knop, Kogiso, Koh, Kojima, Korkaya, Krieg, Kristal, Krystal, Kulbe, Kulshreshtha, Kumar, Kundu, Kundu, Kundu, Kundu, Kundu, Kunter, Kuo, Kurose, Lai, Lanzilli, Lao, Laveti, Lavon, Lazennec, Lee, Lee, Lee, Lee, Lee, Lee, Lee, Lee, Lee, Lee, Lee-Chang, Leibovich-Rivkin, Lerner, Leroy Lowe, Lev-Ari, Lev-Ari, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Lin, Lin, Ling, Lingen, Linsley, Lippitz, Liu, Liu, Liu, Liu, Liu, Liu, Lo, Locksley, Lodish, Loffler, Lombardi, Lopez-Rivera, Lorne J. Hofseth, Lu, Lu, Lu, Luanpitpong, Luigi Ricciardiello, Luthra, Lutz, Ma, Ma, Ma, Ma, Macarthur, Madka, Maheshwari, Makrygiannakis, Malhotra, Malinin, Mann, Mantovani, Mantovani, Mantovani, Marathe, Marcotorchino, Marczylo, Marczylo, Maria Rosa Ciriolo, Marienfeld, Mariette, Marks, Martin, Maru, Maru, Matsunaga, Matysiak, Mavrakis, May, Mazzanti, Melo, Mendell, Meng, Messing, Mestdagh, Meyer-Siegler, Min, Mineharu, Mittelbronn, Miyazawa, Moghaddam, Mohamad, Molnar, Montales, Moore, Moreland, Morris, Mosieniak, Mowla, Mu, Mudduluru, Mukaida, Mukhopadhyay, Murata, Murphy, Murugaiyan, Mutamba, Nakachi, Nakamura, Nakamura, Nakano, Nakasa, Narvaiza, Natoli, Neergheen, Neetu Singh, Neilsen, Nesbitt, Neto, Nishiya, Nishiya, Niwa, Noguchi, Nogueira, Noh, Noh, Noh, Obermajer, Odemis, Ofir, Ogawa, Ogura, Oh, Ohnishi, Olive, Ono, Orlowski, Orosz, Orucevic, Oshima, Oyagbemi, Ozkan, O’Connell, O’Connell, O’Connell, Palapattu, Pallavicini, Palmer, Palozza, Pan, Pan, Pan, Pan, Panis, Papagiannakopoulos, Paplomata, Park, Park, Park, Park, Parker, Pavese, Peiffer, Pendleton, Peng, Pennica, Perkins, Persky, Peters, Philippe, Pichiorri, Plummer, Polivka, Pons, Ponzo, Porkka, Porta, Pouchieu, Privat, Punathil, Pusztai, Qi, Qian, Qin, Qin, Qiu, Rahman, Rajaram, Rakib, Ramon, Rao, Rasheed, Rasyid, Rasyid, Rath, Ravindranath, Reddy, Resch, Richard L. Whelan, Rieder, Ringash, Rioux, Risch, Rissland, Rivas, Rodrigo, Rolle, Romagnani, Rothwell, Rubin, Rupesh Chaturvedi, S. Salman Ashraf, Sahin, Sakai, Salazar, Saleh, Salerno, Sambandam, Sampath, Samuels, Sang, Sarkar, Sarkar, Sartor, Sartor, Scarpino, Schetter, Schetter, Schioppa, Schmid, Schneider, Schols, Schulz, Sen, Shachar, Shah, Shaikh, Shamim, Sharma, Sharma, She, Sheedy, Shen, Shi, Shim, Shimizu, Shimizu, Shimizu, Shimono, Shishodia, Siddiqui, Sies, Silva, Simone, Simpson, Singh, Singh, Singh, Singh, Singh, Singh, Slaby, Smith, Soares Nda, Soini, Somaira Nowsheen, Song, Sonkoly, Srivastava, Stahl, Stambolic, Stanczyk, Stark, Steinbach, Straus, Struyf, Subbaramaiah, Subbaramaiah, Subramaniam, Sukhthankar, Sulma I. Mohammed, Sun, Sun, Sundin, Swana, Syapin, Symonds, Szabolcs, Szewczuk, Taganov, Takada, Takano, Takeshita, Tam, Tam, Tamamura, Tamir, Tan, Tan, Tang, Tang, Tao, Tao, Targownik, Tartaglia, Taylor, Tazzyman, Teodoro, Thai, Thomsen, Thoppil, Tili, Tili, Tili, Tili, Tili, Tili, Toh, Tokuhiro, Tornatore, Tsai, Tschugguel, Tschugguel, Tsubaki, Uppala, Vaidyanathan, Valenti, van den Berg, Van Raemdonck, Vandercappellen, Vaughan, Vaughan, Verbeke, Verbeke, Vergara, Vickers, Villegas, Villegas, Vishvakarma, Vogelstein, Vogt, Volden, Volinia, Vona-Davis, W. Nicol Keith, Wallach, Walle, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Watanabe, Waters, Wei, Wei, Weichselbaum, Weigmann, Weisburger, Weitberg, Welford, Wen, Wesolowska, Whitcomb, Whyte, Wiens, Wietrzyk, Wilken, William G. Helferich, Williams, Wilson, Winner, Wirleitner, Wislez, Witte, Wong, Wong, Woo, Woo, Woodall, Wu, Wu, Wu, Wu, Wu, Xia, Xiao, Xie, Xie, Xie, Xie, Xu, Xu, Xu, Xu, Xu, Xujuan Yang, Yan, Yan, Yang, Yang, Yang, Yang, Yang, Yi, Yoon, Yoshida, Yoshida, Yoshie, Young, Yu, Yu, Yu, Yuan, Yun, Zgheib, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhong, Zhu, Zhu, Zhu, Zintzaras, Zlotogorski +873 morecore +1 more sourceInterplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky +2 morewiley +1 more sourceEarly metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea +9 morewiley +1 more sourceUnderstanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi +3 morewiley +1 more source
