Results 121 to 130 of about 5,576,002 (348)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Respiratory ResearchHighlights FOXO3 was decreased, while LA and FBXO22 were increased in NSCLC patients. LA promoted cisplatin resistance in NSCLC in vitro and in vivo. SQFZ inhibited LA-induced cisplatin resistance in NSCLC by regulating FOXO3.
Wei Bo +4 more
doaj +1 more source
Transarterial RAdioembolization versus ChemoEmbolization for the treatment of hepatocellular carcinoma (TRACE) : study protocol for a randomized controlled trial [PDF]
, 2012 Background: Hepatocellular carcinoma is a primary malignant tumor of the liver that accounts for an important health problem worldwide. Only 10 to 15% of hepatocellular carcinoma patients are suitable candidates for treatment with curative intent, such ...
Al Younis, Imad +11 more
core +1 more source
The role of exosomal PD-L1 in tumor progression and immunotherapy
Molecular Cancer, 2019 Programmed death ligand 1 (PD-L1), a type I transmembrane protein, binds to its receptor PD-1 to suppress the activation of T cells, thereby maintaining immunological homeostasis.
Feiting Xie +4 more
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
Cell Death and Disease, 2019 Lung adenocarcinoma (LUAD) has long been one of the predominant reasons for the global cancer-linked mortality. The tumor progression is shown by several studies to be promoted by increased glycolysis.
Jiayu Zhou +5 more
semanticscholar +1 more source
Inflammation in tumor progression
Folia Pharmacologica Japonica, 2011 転移とは病名であり臨床的知見は大きな価値をもつ．画像診断は転移の空間的情報をもたらすと同時に，その質的な所見は原発巣だけでなく転移巣における組織病理学的知見を支持する．がんの進行は血液・血清学的な変化をもたらし，臨床的に治療の有効性や経過の判断に重要である．この変化する分子や細胞の動態こそが，原発巣が遠隔操作の媒体として遠隔臓器にがん細胞を移動させる手段と考えられる．臨床像に類似性の高い実験動物を利用した転移モデルは存在しないため，樹立された複数の人工的転移系で得られた証拠をもとに多くの転移論が主張されている．われわれの視点もその1つであり，転移臓器における本来の生理的機能の恒常性維持に関与している分子プログラムが原発巣によって質的・量的変化を受けた結果であると考えている．具体的には，肺転移の場合 ...
openaire +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo [PDF]
, 2020 Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.
Cornelius, Lynn A. +6 more
core +1 more source