Results 61 to 70 of about 5,001,621 (350)

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

Science, 2018
SNF'ing out antitumor immunity Immune checkpoint inhibitors induce durable tumor regressions in some, but not all, cancer patients. Understanding the mechanisms that determine tumor sensitivity to these drugs could potentially expand the number of ...
Diana Miao, Claire A. Margolis, Wenhua Gao, M. Voss, Wei Li, D. Martini, Craig K. Norton, D. Bossé, Stephanie A. M. Wankowicz, D. Cullen, C. Horak, M. Wind-Rotolo, A. Tracy, M. Giannakis, F. Hodi, C. Drake, M. Ball, M. Allaf, A. Snyder, M. Hellmann, T. Ho, R. Motzer, S. Signoretti, W. Kaelin, T. Choueiri, E. V. Van Allen   +25 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells [PDF]

, 2012
End Stage Renal Disease (ESRD) is an ever increasing problem worldwide. However the mechanisms underlying disease progression are not fully elucidated. This work addressed the nephrotoxicity induced by the immunosuppressive agents’ cyclosporine A (CsA ...
Ryan, Michael P., Michael P. Ryan, O'Connell, Séin, Slattery, Craig, Tara McMorrow, Craig Slattery, Séin O'Connell, McMorrow, Tara   +7 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Angiomiolipoma renal: presentación de cuatro casos

Revista de la Facultad de Medicina, 1994
EI angiomiolipoma renal es un tumor infrecuente de la corteza renal de naturaleza benigna, compuesto por una mezcla de tejidos en distinta proporción: vasos neoformados, fibras de músculo lisa y tejido adiposo maduro.
Edwin Cagua Agudelo, Fernando Valero Cely, Eugenio Gómez Lloreda, Jorge Luis Paz Bastidas   +3 more
doaj  

Teratoid Wilms′ tumor - A rare renal tumor

Urology Annals, 2011
Teratoid Wilms′ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms′ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy
Biswanath Mukhopadhyay, Ram Mohan Shukla, Madhumita Mukhopadhyay, Sabitri Mandi, Dipankar Roy, Malay K Bhattacharya   +5 more
doaj   +1 more source

A case of ipsilateral three simultaneous renal cell carcinomas with different histologic types

IJU Case Reports, 2023
Introduction Few reports have presented sporadic multifocal renal cell carcinomas of different histologic types occurring simultaneously in a single kidney.
Satoki Tanaka, Yusuke Goto, Ayumi Fujimoto, Takayuki Arai, Hiroaki Sato, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto, Jun‐Ichiro Ikeda, Tomohiko Ichikawa   +9 more
doaj   +1 more source

High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade

Nature Medicine, 2020
Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to immune checkpoint blockade1, this has not been comprehensively evaluated in large randomized studies.
Kobe Yuen, Li-Fen Liu, Vinita Gupta, Shravan Madireddi, Shilpa Keerthivasan, Congfen Li, Deepali Rishipathak, P. Williams, E. Kadel, H. Koeppen, Y. Chen, Z. Modrusan, J. Grogan, R. Banchereau, Ning Leng, A. Thastrom, Xiadong Shen, K. Hashimoto, D. Tayama, M. S. van der Heijden, J. Rosenberg, D. McDermott, T. Powles, P. Hegde, M. Huseni, S. Mariathasan   +25 more
semanticscholar   +1 more source

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source