Results 201 to 210 of about 370,667 (257)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers. [PDF]

Molecules
Maphutha J, Twilley D, Lall N.
europepmc   +1 more source

Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway. [PDF]

BMC Cancer
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C.   +7 more
europepmc   +1 more source

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Tumor suppressor genes

Neuron, 1991
For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular ...
  +7 more sources

Tumor suppressor genes

Current Opinion in Genetics & Development, 2000
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
Tracey L. Plank, Elizabeth Petri Henske
openaire   +3 more sources

Tumor suppressor genes

Current Opinion in Genetics & Development, 1994
The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
openaire   +2 more sources

Oncogenes and tumor suppressor genes

Hospital Practice, 1993
Cancer-associated genes generally can be divided into ‘dominant’ acting protooncogenes/oncogenes and ‘recessive’ tumor suppressor genes. Most simply defined, protooncogenes are identified by a gain of function as mutational damage occurs, whereas tumor suppressor genes contribute to cancer by a loss of function. However, the pace of science leads us to
E, Liu, B, Weissman
openaire   +4 more sources