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Regulation and function of the p53 tumor suppressor protein
Current Opinion in Cell Biology, 2001Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
Kevin M Ryan, Andrew C Phillips
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p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs
Veterinary Pathology, 1996Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
C G Couto, C C Capen
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Activation of the p53 tumor suppressor protein
Biochimica Et Biophysica Acta: Reviews on Cancer, 2002The p53 tumor suppressor gene plays an important role in preventing cancer development, by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full ...
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Interaction of Tumor Suppressor p53 with DNA and Proteins
Current Pharmaceutical Biotechnology, 2010p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and ...
Jianxiu, Wang, Julei, Yang
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The P53 Tumor Suppressor Protein
1995In response to damaged DNA, mammalian cell growth is arrested at cell cycle checkpoints in Gl, near the border of S phase, or in G2, before mitosis (Murray, 1992; Hunter, 1993; Weinert and Lydall, 1993). In some circumstances, DNA damage initiates apoptosis, a program that results in cell death.
Ettore Appella +7 more
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