Results 231 to 240 of about 148,781 (262)

Refolding and structural characterization of the human p53 tumor suppressor protein

Biophysical Chemistry, 2002
The human tumor suppressor p53 is a conformationally flexible and functionally complex protein that is only partially understood on a structural level. We expressed full-length p53 in the cytosol of Escherichia coli as inclusion bodies. To obtain active, recombinant p53, we varied renaturation conditions using DNA binding activity and oligomeric state ...
Stefan, Bell, Silke, Hansen, Johannes, Buchner   +2 more
openaire   +2 more sources

Transcriptional Repression by the p53 Tumor Suppressor Protein

2005
In addition to its well-characterized function as a sequence specific transcriptional activator, there is growing evidence that the p53 tumor suppressor protein is also a sequence-specific transcriptional repressor. The concept that a transcription factor can exist as both an activator and a repressor of transcription is not new.
Jack T. Zilfou, Maureen E. Murphy
openaire   +1 more source

Tumor suppressor p53 and TRIM family proteins

Cancer Cell & Microenvironment, 2015
Tumor suppressor p53 plays a key role in maintaining genomic stability and tumor suppression. As a transcription factor, p53 mainly exerts its function in tumor suppression through transcriptional regulation of its target genes to regulate a wide variety of cellular responses. To maintain its proper function, p53 protein levels and activity are tightly
openaire   +1 more source

Regulation of the p53 tumor suppressor by ribosomal proteins

2009
The capacity to detect and appropriately respond to many different stresses that interfere with functional homeostasis is essential for organismal survival. Recent evidence suggests that the nucleolus, the site of ribosome biogenesis, plays a critical role in sensing and responding to many external and internal stresses.
openaire   +4 more sources

Cellular Proteins Interacting with the Tumor Suppressor Protein p53.

1995
Abstract : Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand DNA. We defined the domain of p53 that bound to RPA and constructed p53 mutants that failed to bind RPA, but still functioned as transcriptional activators.
openaire   +1 more source

Stability and Ubiquitination of the Tumor Suppressor Protein p53

2003
Lesley J, Jardine, Carl G, Maki
openaire   +2 more sources

Detection of tumor suppressor protein p53 with special emphasis on biosensors: A review

Analytical Biochemistry, 2020
Shikha Pundir, C S Pundir, C S Pundir
exaly  

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

Journal of Cell Biology, 2001
Junjie Chen, K Iwabuchi, Date Takayasu   +2 more
exaly  

Oncogenes and tumor suppressor genes

Ca-A Cancer Journal for Clinicians, 1994
Robert A Weinberg
exaly  

The p53 Tumor Suppressor Gene and Nuclear Protein: Basic Science Review and Relevance in the Management of Bladder Cancer

Journal of Urology, 2003
Scott Eggener, Norm D Smith, James M Kozlowski   +2 more
exaly