Results 241 to 250 of about 233,797 (295)

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Identification of DMP1 as Novel p53 Repressed Transcriptional Target. [PDF]

Int J Mol Sci
Xu J, Britschgi C, Arvidsson G, Krauer D, Zlobec I, Torbett BE, Tschan MP.   +6 more
europepmc   +1 more source

The role of Alanyl-tRNA synthetase 1 lactylation in tumors and other diseases. [PDF]

Discov Oncol
Zhou XY, Zhou XJ.
europepmc   +1 more source

WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma. [PDF]

Proc Natl Acad Sci U S A
Bidany-Mizrahi T, Maroun K, Mancini M, Hidmi O, Ansari I, Monin J, Keidar Haran T, Maly A, Melino G, Candi E, Aqeilan RI.   +10 more
europepmc   +1 more source

RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review). [PDF]

Int J Mol Med
Liu S, Ma Z, Ji B, Zhu J, Yao S, Terai S, Tuo B, Li T, Liu X.   +8 more
europepmc   +1 more source

Biomarkers of Common Molecular Dysregulation in Tumor Tissue and Peritumor Mucosa in Head and Neck SCC: Insights into Field Cancerization. [PDF]

Int J Mol Sci
Dimitrov L, Stancheva GS, Kyurkchiyan SG, Mitkova M, Stancheva I, Valcheva S, Komitova K, Skelina S, Rangachev J, Popov TM.   +9 more
europepmc   +1 more source

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Regulation and function of the p53 tumor suppressor protein

Current Opinion in Cell Biology, 2001
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
K M, Ryan, A C, Phillips, K H, Vousden
openaire   +4 more sources

Posttranslational Regulation of p53 Tumor Suppressor Protein Function

Critical Reviews™ in Oncogenesis, 1994
Alteration of the p53 gene by deletion and mutation is the most common denominator yet identified among human cancers (Hollstein et al., 1991; Caron de Fromental and Soussi, 1992). The involvement of the p53 gene in such a broad scope of human cancers warrants further investigation into its mechanism of action in regulating cell growth.
S A, Maxwell, J A, Roth
openaire   +2 more sources