Results 261 to 270 of about 233,797 (295)
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Tumor suppressor protein p53 and anti‐p53 autoantibodies in pediatric rheumatological diseases
Pediatric Allergy and Immunology, 2003The tumor suppressor protein p53 plays an important role in cell cycle regulation. One of the major features in rheumatic diseases is the abnormal proliferation of lymphocytes. p53 expression in peripheral blood mononuclear cells (by flowcytometry) and serum anti‐p53 antibodies (by ELISA) were therefore measured in 18 children and adolescents with ...
Zeinab Awad, El-Sayed +2 more
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Unique complex between bacterial azurin and tumor-suppressor protein p53
Biochemical and Biophysical Research Communications, 2005The tumor-suppressor protein p53 is a major player in regulation of cell growth, genomic stability, and cell death. Recent work suggests that Pseudomonas aeruginosa azurin, as the only bacterial protein known to date, can enter cancer cells and interact with p53 promoting cell death.
David, Apiyo +1 more
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Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx
Cancer Letters, 2009The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stability of HBx protein. Overexpression of
Sung Gyoo, Park +4 more
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Transcriptional Repression by the p53 Tumor Suppressor Protein
2005In addition to its well-characterized function as a sequence specific transcriptional activator, there is growing evidence that the p53 tumor suppressor protein is also a sequence-specific transcriptional repressor. The concept that a transcription factor can exist as both an activator and a repressor of transcription is not new.
Jack T. Zilfou, Maureen E. Murphy
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The tumor suppressor protein p53
Current Opinion in Oncology, 1995The p53 protein is a transcription regulator that is frequently altered by mutation in cancer. Breakthroughs on two fronts shed light on its role in tumor suppression. First, a flurry of biochemical and structural studies (including a partial crystal structure) has sharpened the picture of p53 topology and functional properties.
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Cellular Proteins Interacting with the Tumor Suppressor Protein p53.
1995Abstract : Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand DNA. We defined the domain of p53 that bound to RPA and constructed p53 mutants that failed to bind RPA, but still functioned as transcriptional activators.
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Drugging p53 in cancer: one protein, many targets
Nature Reviews Drug Discovery, 2022Ori Hassin, Moshe Oren
exaly
Interaction of the Tumor Suppressor p53 With Replication Protein A.
1995Abstract : The DNA replication factor RPA physically associates with the tumor suppressor protein p53, an interaction that could be important for the function of both these proteins in normal and cancer cells. Using two mutant forms of p53 with the desired property of not binding RPA we have demonstrated that RPA binding is not required for growth ...
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Regulation of the p53 tumor suppressor by ribosomal proteins
2009The capacity to detect and appropriately respond to many different stresses that interfere with functional homeostasis is essential for organismal survival. Recent evidence suggests that the nucleolus, the site of ribosome biogenesis, plays a critical role in sensing and responding to many external and internal stresses.
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