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Immunohistochemistry for p16 and p53 Provides Substantial Agreement With Molecular Tests in Penile Cancer. [PDF]

Pathol Int
Hrudka J, Hojný J, Krkavcová E, Dvořák J, Prouzová Z, Bártů MK, Zavillová N, Čapka D, Matěj R, Waldauf P.   +9 more
europepmc   +1 more source

MicroRNA-regulated signaling and tumor microenvironment modulation in lung cancer: mechanistic insights and translational opportunities. [PDF]

Cancer Cell Int
Shrestha C, Brito S, Deshar B, Cho J, Lee G, Jung D, Park J, Min KS, Chae YK, Kim J.   +9 more
europepmc   +1 more source

Regulation and function of the p53 tumor suppressor protein

Current Opinion in Cell Biology, 2001
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription.
Kevin M Ryan, Andrew C Phillips, Karen H Vousden   +2 more
exaly   +4 more sources

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Activation of the p53 tumor suppressor protein

Biochimica Et Biophysica Acta: Reviews on Cancer, 2002
The p53 tumor suppressor gene plays an important role in preventing cancer development, by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full ...
Karen H Vousden
exaly   +3 more sources

p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs

Veterinary Pathology, 1996
Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
C G Couto, Charles C Capen
exaly   +3 more sources

Interaction of Tumor Suppressor p53 with DNA and Proteins

Current Pharmaceutical Biotechnology, 2010
p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and ...
Jianxiu, Wang, Julei, Yang
openaire   +2 more sources

MDM2 — master regulator of the p53 tumor suppressor protein

Gene, 2000
MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by increasing its susceptibility to proteolysis by the 26S proteosome. Immediately after the application of cellular stress, the ability of MDM2 to bind to p53 is blocked or ...
J, Momand, H H, Wu, G, Dasgupta
openaire   +2 more sources

The P53 Tumor Suppressor Protein

1995
In response to damaged DNA, mammalian cell growth is arrested at cell cycle checkpoints in Gl, near the border of S phase, or in G2, before mitosis (Murray, 1992; Hunter, 1993; Weinert and Lydall, 1993). In some circumstances, DNA damage initiates apoptosis, a program that results in cell death.
Ettore Appella, Kazuyasu Sakaguchi, Hiroshi Sakamoto, Marc S. Lewis, James G. Omichinski, Angela M. Gronenborn, G. Marius Clore, Carl W. Anderson   +7 more
openaire   +1 more source

Effect of Phosphorylation on Tetramerization of the Tumor Suppressor Protein p53

Journal of Protein Chemistry, 1997
Human tumor suppressor protein p53 is a 393-amino acid phosphoprotein that enhances transcription in response to DNA damage from several genes that regulate cell cycle progression. The tetrameric state of p53 is critical to wild-type function; the p53 tetramerization element is located in the C-terminal region of the protein.
K, Sakaguchi, H, Sakamoto, D, Xie, J W, Erickson, M S, Lewis, C W, Anderson, E, Appella   +6 more
openaire   +2 more sources