Results 281 to 290 of about 154,391 (307)

Transcriptional Repression by the p53 Tumor Suppressor Protein

2005
In addition to its well-characterized function as a sequence specific transcriptional activator, there is growing evidence that the p53 tumor suppressor protein is also a sequence-specific transcriptional repressor. The concept that a transcription factor can exist as both an activator and a repressor of transcription is not new.
Jack T. Zilfou, Maureen E. Murphy
openaire   +1 more source

Regulation of the p53 tumor suppressor by ribosomal proteins

2009
The capacity to detect and appropriately respond to many different stresses that interfere with functional homeostasis is essential for organismal survival. Recent evidence suggests that the nucleolus, the site of ribosome biogenesis, plays a critical role in sensing and responding to many external and internal stresses.
openaire   +4 more sources

Cellular Proteins Interacting with the Tumor Suppressor Protein p53.

1995
Abstract : Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand DNA. We defined the domain of p53 that bound to RPA and constructed p53 mutants that failed to bind RPA, but still functioned as transcriptional activators.
openaire   +1 more source

Detection of tumor suppressor protein p53 with special emphasis on biosensors: A review

Analytical Biochemistry, 2020
Shikha Pundir, C S Pundir, C S Pundir
exaly  

Stability and Ubiquitination of the Tumor Suppressor Protein p53

2003
Lesley J, Jardine, Carl G, Maki
openaire   +2 more sources

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

Journal of Cell Biology, 2001
Kuniyoshi Iwabuchi, Takayasu Date, Junjie Chen   +2 more
exaly  

Unique complex between bacterial azurin and tumor-suppressor protein p53

Biochemical and Biophysical Research Communications, 2005
Pernilla Wittung-Stafshede
exaly  

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Cancer Cell, 2017
Stephano S Mello, Liz J Valente, Nitin Raj   +2 more
exaly  

p53 Tumor Suppressor Protein

2006
openaire   +1 more source

The p53 Tumor Suppressor Gene and Nuclear Protein: Basic Science Review and Relevance in the Management of Bladder Cancer

Journal of Urology, 2003
Norm D Smith, Jonathan N Rubenstein, Scott E Eggener   +2 more
exaly