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Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis
The Journal of Dermatology, 1996AbstractWe examined 9 Japanese cases of porokeratosis (4 of the plaque type, 2 of disseminated superficial actinic porokeratosis, 2 of disseminated superficial porokeratosis, and one of giant porokeratosis) for the expression of p53 tumor suppressor protein immunohistochemically, using two anti‐p53 antibodies, CM1 and DO1.
Y, Urano +4 more
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2001
The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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Functional dissection of p53 tumor suppressor protein
1997Publisher Summary This chapter discusses the functional dissection of p53 tumor suppressor protein. The p53 tumor suppressor protein plays a pivotal role in tumor suppression and is mutated very frequently in many forms of human cancer. Stress signals such as DNA damage and hypoxia cause the induction and activation of p53 in normal cells with the ...
L, Jayaraman, E, Freulich, C, Prives
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Posttranslational Regulation of p53 Tumor Suppressor Protein Function
Critical Reviews™ in Oncogenesis, 1994Alteration of the p53 gene by deletion and mutation is the most common denominator yet identified among human cancers (Hollstein et al., 1991; Caron de Fromental and Soussi, 1992). The involvement of the p53 gene in such a broad scope of human cancers warrants further investigation into its mechanism of action in regulating cell growth.
S A, Maxwell, J A, Roth
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Overexpression of p53 Tumor Suppressor Protein in Porokeratosis
Archives of Dermatology, 1994Background: p53 is a tumor suppressor nucleoprotein. Mutations of the p53 gene have been found in a variety of malignant neoplasms. Wild-type p53 has a short half-life, possibly only 20 to 30 minutes, and is not present in the nucleus at levels that are detectable with routine immunohistochemical techniques.
J W, Magee, T H, McCalmont, P E, LeBoit
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Interaction of the Tumor Suppressor p53 With Replication Protein A.
1995Abstract : The DNA replication factor RPA physically associates with the tumor suppressor protein p53, an interaction that could be important for the function of both these proteins in normal and cancer cells. Using two mutant forms of p53 with the desired property of not binding RPA we have demonstrated that RPA binding is not required for growth ...
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Tumor suppressor protein p53 and anti‐p53 autoantibodies in pediatric rheumatological diseases
Pediatric Allergy and Immunology, 2003The tumor suppressor protein p53 plays an important role in cell cycle regulation. One of the major features in rheumatic diseases is the abnormal proliferation of lymphocytes. p53 expression in peripheral blood mononuclear cells (by flowcytometry) and serum anti‐p53 antibodies (by ELISA) were therefore measured in 18 children and adolescents with ...
Zeinab Awad, El-Sayed +2 more
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The tumor suppressor protein p53
Current Opinion in Oncology, 1995The p53 protein is a transcription regulator that is frequently altered by mutation in cancer. Breakthroughs on two fronts shed light on its role in tumor suppression. First, a flurry of biochemical and structural studies (including a partial crystal structure) has sharpened the picture of p53 topology and functional properties.
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Refolding and structural characterization of the human p53 tumor suppressor protein
Biophysical Chemistry, 2002The human tumor suppressor p53 is a conformationally flexible and functionally complex protein that is only partially understood on a structural level. We expressed full-length p53 in the cytosol of Escherichia coli as inclusion bodies. To obtain active, recombinant p53, we varied renaturation conditions using DNA binding activity and oligomeric state ...
Stefan, Bell +2 more
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Tumor suppressor p53 and TRIM family proteins
Cancer Cell & Microenvironment, 2015Tumor suppressor p53 plays a key role in maintaining genomic stability and tumor suppression. As a transcription factor, p53 mainly exerts its function in tumor suppression through transcriptional regulation of its target genes to regulate a wide variety of cellular responses. To maintain its proper function, p53 protein levels and activity are tightly
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