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p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs
Veterinary Pathology, 1996Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
J E, Sagartz +5 more
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2001
The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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Functional dissection of p53 tumor suppressor protein
1997Publisher Summary This chapter discusses the functional dissection of p53 tumor suppressor protein. The p53 tumor suppressor protein plays a pivotal role in tumor suppression and is mutated very frequently in many forms of human cancer. Stress signals such as DNA damage and hypoxia cause the induction and activation of p53 in normal cells with the ...
L, Jayaraman, E, Freulich, C, Prives
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Interaction of Tumor Suppressor p53 with DNA and Proteins
Current Pharmaceutical Biotechnology, 2010p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and ...
Jianxiu, Wang, Julei, Yang
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The P53 Tumor Suppressor Protein
1995In response to damaged DNA, mammalian cell growth is arrested at cell cycle checkpoints in Gl, near the border of S phase, or in G2, before mitosis (Murray, 1992; Hunter, 1993; Weinert and Lydall, 1993). In some circumstances, DNA damage initiates apoptosis, a program that results in cell death.
Ettore Appella +7 more
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Activation of the p53 tumor suppressor protein
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002The p53 tumor suppressor gene plays an important role in preventing cancer development, by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full ...
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MDM2 — master regulator of the p53 tumor suppressor protein
Gene, 2000MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by increasing its susceptibility to proteolysis by the 26S proteosome. Immediately after the application of cellular stress, the ability of MDM2 to bind to p53 is blocked or ...
J, Momand, H H, Wu, G, Dasgupta
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Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis
The Journal of Dermatology, 1996AbstractWe examined 9 Japanese cases of porokeratosis (4 of the plaque type, 2 of disseminated superficial actinic porokeratosis, 2 of disseminated superficial porokeratosis, and one of giant porokeratosis) for the expression of p53 tumor suppressor protein immunohistochemically, using two anti‐p53 antibodies, CM1 and DO1.
Y, Urano +4 more
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Tumor suppressor p53 and TRIM family proteins
Cancer Cell & Microenvironment, 2015Tumor suppressor p53 plays a key role in maintaining genomic stability and tumor suppression. As a transcription factor, p53 mainly exerts its function in tumor suppression through transcriptional regulation of its target genes to regulate a wide variety of cellular responses. To maintain its proper function, p53 protein levels and activity are tightly
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Overexpression of p53 tumor suppressor protein in porokeratosis.
Archives of dermatology, 1994p53 is a tumor suppressor nucleoprotein. Mutations of the p53 gene have been found in a variety of malignant neoplasms. Wild-type p53 has a short half-life, possibly only 20 to 30 minutes, and is not present in the nucleus at levels that are detectable with routine immunohistochemical techniques.
J W, Magee, T H, McCalmont, P E, LeBoit
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