Results 41 to 50 of about 9,826,714 (353)
Advancement of science, 2020 Immunotherapy aiming to harness the exquisite power of the immune system has emerged as a crucial part of clinical cancer management. However, only a subset of cancer patients responds to current immunotherapy because of low immunogenicity of the tumor ...
Xian-li Hu +10 more
semanticscholar +1 more source
Targeting Tumor Vascular CD99 Inhibits Tumor Growth [PDF]
Frontiers in Immunology, 2019 CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors.
Huijbers, Elisabeth J.M. +9 more
openaire +5 more sources
Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity
Scientific Reports, 2017 To explore dendritic cells/tumor-derived endothelial cells (DC/EC) fusion cells are potent stimulators of T cells to impact tumor progression. ECs were isolated from mice hepatoma cell line (H22) Xenograft, and dendritic cells were isolated from bone ...
Yingying Huang +9 more
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Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]
, 2017 Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio +3 more
core +2 more sources
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]
, 2016 Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M +5 more
core +2 more sources
Tumor Targeting via Integrin Ligands [PDF]
Frontiers in Oncology, 2013 Selective and targeted delivery of drugs to tumors is a major challenge for an effective cancer therapy and also to overcome the side-effects associated with current treatments. Overexpression of various receptors on tumor cells is a characteristic structural and biochemical aspect of tumors and distinguishes them from physiologically normal cells ...
Udaya Kiran eMarelli +5 more
openaire +5 more sources
Progress on the roles of MEF2C in neuropsychiatric diseases
Molecular Brain, 2022 Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites.
Zhikun Zhang, Yongxiang Zhao
doaj +1 more source
Pyroptosis, a New Breakthrough in Cancer Treatment
Frontiers in Oncology, 2021 The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response.
Dengqiang Wu +5 more
doaj +1 more source
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
International Journal of Molecular Sciences, 2019 The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in regulation of cell survival, metabolism, growth and protein synthesis in response to upstream signals in both normal physiological and pathological conditions ...
Tian Tian, Xiaoyi Li, Jinhua Zhang
semanticscholar +1 more source
Enhancement of EPR Effect for Passive Tumor Targeting: Current Status and Future Perspectives
Applied SciencesThe Enhanced Permeability and Retention (EPR) effect is a key mechanism for passive tumor targeting, which involves the selective accumulation of therapeutic nanoparticles in tumors due to their unique vascular characteristics.
Ioanna-Aglaia Vagena +4 more
semanticscholar +1 more source