Results 21 to 30 of about 774,346 (269)
Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity
Scientific Reports, 2017 To explore dendritic cells/tumor-derived endothelial cells (DC/EC) fusion cells are potent stimulators of T cells to impact tumor progression. ECs were isolated from mice hepatoma cell line (H22) Xenograft, and dendritic cells were isolated from bone ...
Yingying Huang +9 more
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Targeting tumor-associated macrophages in the tumor microenvironment.
Oncology letters, 2020 Tumor-associated macrophages (TAMs) are the most abundant population type of tumor-infiltrating immune cells found in the tumor microenvironment (TME), and are evolutionarily associated with microvessel density in tumor tissues. TAMs can be broadly divided into M1-like and M2-like TAMs, which demonstrate antitumor and pro-tumor activity in the TME ...
Zhou, Kaiwen +7 more
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Pyroptosis, a New Breakthrough in Cancer Treatment
Frontiers in Oncology, 2021 The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response.
Dengqiang Wu +5 more
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Progress on the roles of MEF2C in neuropsychiatric diseases
Molecular Brain, 2022 Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites.
Zhikun Zhang, Yongxiang Zhao
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Targeting the LKB1 Tumor Suppressor [PDF]
Current Drug Targets, 2014 LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers. Physiologically, LKB1 possesses multiple cellular functions in the regulation of cell bioenergetics metabolism, cell cycle arrest, embryo development, cell polarity, and apoptosis.
Rui-Xun, Zhao, Zhi-Xiang, Xu
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BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
Nanoscale Research Letters, 2021 The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration.
Shubi Zhao +7 more
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Tumor Microenvironment Targeted Nanotherapy [PDF]
Frontiers in Pharmacology, 2018 Recent developments in nanotechnology have brought new approaches to cancer diagnosis and therapy. While enhanced permeability and retention effect promotes nano-chemotherapeutics extravasation, the abnormal tumor vasculature, high interstitial pressure and dense stroma structure limit homogeneous intratumoral distribution of nano-chemotherapeutics and
Clara Fernandes +2 more
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Targeting of drugs and nanoparticles to tumors [PDF]
The Journal of Experimental Medicine, 2010 The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as docking sites to concentrate drug conjugates and nanoparticles at tumors. Specific markers in tumor vessels are particularly well suited
Ruoslahti, Erkki +2 more
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The Involvement of Ascorbic Acid in Cancer Treatment
MoleculesVitamin C (VC), also known as ascorbic acid, plays a crucial role as a water-soluble nutrient within the human body, contributing to a variety of metabolic processes.
Di Guo +8 more
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Targeting Angiogenesis and the Tumor Microenvironment [PDF]
Surgical Oncology Clinics of North America, 2013 The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types.
Jennifer, Samples +2 more
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