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Advanced MaterialsAbstractNanomedicines are extensively explored for cancer therapy. By delivering drug molecules more efficiently to pathological sites and by attenuating their accumulation in healthy organs and tissues, nanomedicine formulations aim to improve the balance between drug efficacy and toxicity.
Twan Lammers
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BMC Cancer, 2023 Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells.
Shane O’Brien +8 more
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Targeting the tumor microenvironment [PDF]
Frontiers in Bioscience, 2007 Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
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Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy
Frontiers in Oncology, 2021 Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer.
Jianfeng Hua +8 more
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Signal Amplification-Based Biosensors and Application in RNA Tumor Markers
Sensors, 2023 Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated
Haiping Li +7 more
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Targeting Tumors Using Peptides [PDF]
Molecules, 2020 To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure of solid tumors, the penetration of higher Mw compounds is unfavored and being small thus becomes an advantage. This review covers
Pablo Scodeller, Eliana K. Asciutto
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Study of Oncolytic Virus Preservation and Formulation
Pharmaceuticals, 2023 In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying ...
Lina Pan +6 more
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Targeting Toxins toward Tumors [PDF]
Molecules, 2021 Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer diseases only a minor part of the malignant cells will be in a proliferative state, and consequently these drugs will exert a ...
Henrik Franzyk +1 more
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Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Journal of Translational Medicine, 2023 Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen +7 more
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Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Chinese Medical Journal, 2021 . Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells
Shao-Dan Liu +4 more
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