Results 131 to 140 of about 57,172 (289)
BJU International, EarlyView.Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa +5 more
wiley +1 more source
BJU International, EarlyView.Objective To clarify the impact of chromosomal aberrations on the offspring of patients with testicular germ cell tumour (TGCT) by evaluating the outcomes of intracytoplasmic sperm injection (ICSI). Patients and Methods Under the ethical review of Yokohama City University, 12 patients with TGCT and 25 with non‐TGCT cancer who had cryopreserved sperm ...
Haru Hamada +21 more
wiley +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, EarlyView.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
[Juvenile granulosa cell tumor-Testicular tumor of the very young : Report of three cases and contemporary recommendations]. [PDF]
Urologe A, 2021 Haider M +3 more
europepmc +1 more source
Exercício e efeitos da Doxorubicina na função testicular
, 2012 Mestrado em Biomedicina MolecularA Doxorubicina (DOX) é um agente antineoplásico de grande eficácia utilizado no tratamento de vários tipos de tumores. No entanto, a sua utilização clínica é limitada devido à sua toxicidade em vários órgãos, com destaque
Ferreira, André
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RETROPERITONEAL LYMPHNODE DISSECTION FOR TESTICULAR TUMOR [PDF]
, 1975 Eighteen cases of testicular tumor were treated in our department for two years from September 1972 to August 1974, and in fourteen cases bilateral radical transperitoneal lymphnode dissection was performed.
沼田, 正紀, 高崎, 登, 出村, 愰
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Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management
Clinical Endocrinology, EarlyView.ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu +5 more
wiley +1 more source
Testicular neuroendocrine tumor in a 32‐year‐old man: A case report
Clinical Case ReportsKey Clinical Message A 32‐year‐old male with painful scrotal swelling who underwent radical orchiectomy and was diagnosed with a testicular neuroendocrine tumor.
Reza Dehghaniathar +2 more
doaj +1 more source
Testicular leydig cell tumor in a child: a case report [PDF]
, 1989 A 7-year-old boy was admitted to the department of pediatrics in our hospital with the complaint of sexual precocity manifested by a growth spurt, penile enlargement and pubic hair development.
大川, 光央 +8 more
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Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source