Results 111 to 120 of about 90,749 (281)

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, EarlyView.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

Andrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner, Ramtin Zargari Marandi, Jakob Lauritsen, Daniel Dawson Murray, Mikkel Bandak, Birgitte Grønkær Toft, Dan Berney, Gedske Daugaard   +7 more
wiley   +1 more source

A case of late stage bilateral testicular adrenal rest tumor in 11-beta-hydroxylase deficiency

Urology Research and Practice, 2019
A 23-year-old man was admitted to our outpatient clinic complaining of infertility and bilateral testicular masses. At physical examination nodular lesions were detected in bilateral testes. The medical history revealed congenital adrenal hyperplasia due
Osman Ergün, Ahmet Güzel, Mehmet Numan Tamer, Sema Bircan, Abdullah Armağan   +4 more
doaj   +2 more sources

Rare Testicular Tumor Discovered by Assault: An Unusual Presentation of a Primary Testicular Neuroendocrine Tumor Grade 2

Case Reports in Pathology, 2013
Testicular neuroendocrine tumors (NET) or carcinoid tumors are rare neoplasms which represent 1% of all testicular tumors and can be divided into 3 subgroups: pure primary testicular NET, primary testicular NET associated with a teratoma, and NET ...
Jonathan R. Epperson, Necia M. Pope, Margaret J. Abuzeid   +2 more
doaj   +1 more source

[Juvenile granulosa cell tumor-Testicular tumor of the very young : Report of three cases and contemporary recommendations]. [PDF]

Urologe A, 2021
Haider M, Comploj E, Hofmann A, Rösch WH.   +3 more
europepmc   +1 more source

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Nut Consumption and Sperm Quality in Healthy Men: Results From the Led‐Fertyl Study

Andrology, EarlyView.
ABSTRACT Background Nuts are rich in antioxidants and other bioactive compounds, and recent evidence suggests that their regular consumption may be associated with sperm quality. However, the current scientific evidence remains limited and inconsistent.
Estefanía Dávila‐Córdova, Nancy Babio, Cristina Valle‐Hita, María Fernández de la Puente, Alfonso Beltran‐Arasa, Miguel Cebrián‐Puig, Violeta Fambuena‐Perez, Iván García‐Serrano, Michelle M. Murphy, Jordi Salas‐Salvadó, Albert Salas‐Huetos   +10 more
wiley   +1 more source

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor, Oishee Bandyopadhyay, Nahian Ahmed, Kapishan Shanmugathasan, Alice Cotton, ChingHao Chen, Tet Yap   +6 more
wiley   +1 more source