Results 61 to 70 of about 91,211 (282)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Blood mir-331-3p is a potential diagnostic marker for giant panda (Ailuropoda melanoleuca) testicular tumor

BMC Veterinary Research
Background In recent years, several giant pandas have suffered from testicular tumor, which has seriously affected giant panda health. However, the pathogenesis of testicular tumor in giant panda is still unclear.
Yan Zhu, Zhi Huang, Caiwu Li, Chengyao Li, Ming Wei, Linhua Deng, Wenwen Deng, Xiao Zhou, Kai Wu, Bo Yang, Yuanyuan Qu, Qin Liu, Xuemei Chen, Desheng Li, Chengdong Wang   +14 more
doaj   +1 more source

Espermatocelectomía como Tratamiento Quirúrgico Definitivo para el Quiste de Epidídimo. Espermatozoides Vivos: Reporte de un Caso

Revista Guatemalteca de Urología
Se presenta un paciente masculino de 35 años de edad, que acudió a consulta externa de Urología por presentar aumento de volumen hemiescrotal izquierdo, se realizó diagnóstico de quiste epidídimo, se realizó tratamiento quirúrgico mediante ...
Lázaro Deinys Rodríguez Borrego, Jorge Amed Fernández Pérez , Grisel Pérez Merique   +2 more
doaj   +1 more source

Immunoreactive human chorionic gonadotropin and its free ß-subunit in serum and ascites of patients with malignant tumors [PDF]

, 1992
Human chorionic gonadotropin (hCG) is a clinically relevant marker of trophoblastic and nontrophoblastic malignancies. In the present studies, in addition to determining serum hCG, we investigated the presence and properties of hCG immunoreactivity in ...
Gerbes, Alexander L., Hörmann, Rudolf, Jüngst, Dieter, Mann, Klaus, Spöttl, Gerald   +4 more
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

COMBINED TREATMENT OF A PATIENT WITH A TESTICULAR GERM CELL TUMOR WITH SIGNS OF MULTIPLE ORGAN FAILURE

Исследования и практика в медицине, 2019
Testicular cancer is a rare malignant tumor. In the structure of general cancer incidence, this nosology accounts for about 1–1.5% of cases. Among this pathology, about 90–95% is due to testicular germ cell tumors.
T. V. Ustinova, L. V. Bolotina, A. A. Fedenko, H. S. Gevorgyan, A. A. Paichadze, A. L. Kornietskaya, N. V. Vorobyev, K. M. Nushko, A. S. Kalpinskiy, A. A. Kachmazov, K. M. Isaeva   +10 more
doaj   +1 more source

Complete remission of Cdx-2 positive primary testicular carcinoid tumor: 10-years follow-up and literature review

BMC Urology, 2020
Background The neuroendocrine cells can cause a variety of malignancies throughout the human body known as the neuroendocrine tumors (NETs) or carcinoid tumors.
Eugen Widmeier, Hannah Füllgraf, Cornelius F. Waller   +2 more
doaj   +1 more source

Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection [PDF]

, 1984
Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection.
Bron, K, Dekker, A, Iwatsuki, S, Kowal, C, Mittal, R, Schade, R, Starzl, T, Straub, W, Van Thiel, D   +8 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bilateral Synchronous Testicular Seminoma in a Patient with Bilateral Cryptorchidism

Journal of Nepal Medical Association, 2014
Cryptorchidism is a known cause of testicular tumor. The incidence of testicular tumor is 11 times more in inguinal testes and 50 times more in intra-abdominal testes.
Dilasma Ghartimagar, Arnab Ghosh, Manish Krishna Shrestha, Duk Bahadur Chettri, Santosh Shrestha, Rishi Kumar Sherchan   +5 more
doaj   +3 more sources