Results 281 to 290 of about 3,547,100 (335)

Therapeutic targeting of the tumor vasculature

Seminars in Radiation Oncology, 2004
A functional tumor vasculature is essential for tumor growth and metastasis and makes an attractive target for therapy. Both antiangiogenic and antivascular approaches are being developed for this purpose. In this article, the current antiangiogenic and antivascular approaches to cancer therapy, potential for their combination with radiotherapy ...
Gillian M, Tozer, Roy, Bicknell
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CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges

Recent Patents on Anti-Cancer Drug Discovery, 2012
CXCL12, also known as SDF-1, is the single natural ligand for chemokine receptors CXCR4 and CXCR7. CXCL12 has angiogenic properties in normal endothelial tissue and is involved in the outgrowth and metastasis of CXCR4 expressing tumors. Recent investigations have indicated that CXCL12 levels increase after chemo- and anti- VEGF therapy, favouring ...
de NIGRIS, Filomena, Schiano C, Infante T, NAPOLI, Claudio   +3 more
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Tumors of the pulmonary vasculature

Cardiology Clinics, 2004
Most primary tumors of the pulmonary vasculature are sarcomas arising in the main pulmonary arteries and veins with high mortality rates. Pulmonary artery sarcoma is far more prevalent than its venous counterpart, though both are rare. Pulmonary capillary hemangiomatosis is a rare low-grade tumor or tumor-like lesion of the pulmonary capillaries that ...
openaire   +2 more sources

Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

Journal of Controlled Release, 2003
Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at angiogenic tumor endothelial cells was developed. Alpha v beta 3-integrins are overexpressed on actively proliferating endothelium and represent a possible ...
Schiffelers, R.M., Koning, G.A., ten Hagen, T.L.M., Fens, M.H.A.M., Schraa, A.J., Janssen, A.P.C.A., Kok, R.J., Molema, G., Storm, G.   +8 more
openaire   +3 more sources

Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation.

ACS Nano, 2018
Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability and retention (EPR) effect, but it remains challenging to decipher the exact impact of the EPR effect.
Haofei Wang, R. Ran, Yun Liu, Yue Hui, Bijun Zeng, Dong Chen, D. Weitz, Chun‐Xia Zhao   +7 more
semanticscholar   +1 more source

Quantifying Tumor and Vasculature Deformations during Laryngoscopy

Annals of Biomedical Engineering, 2022
Retractors and scopes used in head and neck surgery to provide adequate surgical exposure also deform critical structures in the region. Surgeons typically use preoperative imaging to plan and guide their tumor resections, however the large tissue deformation resulting from placement of retractors and scopes reduces the utility of preoperative imaging ...
Xiaotian Wu, David A. Pastel, Rihan Khan, Clifford J. Eskey, Yuan Shi, Michael Sramek, Joseph A. Paydarfar, Ryan J. Halter   +7 more
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Ultra-small nanocluster mediated synthesis of Nd3+-doped core-shell nanocrystals with emission in the second near-infrared window for multimodal imaging of tumor vasculature.

Biomaterials, 2018
In-vivo intravital short wavelength infrared (SWIR, 1000-2300 nm) fluorescence imaging has attracted considerable attention in the imaging of tumor vasculature due to its low background, high sensitivity, and deep penetration.
Feng Ren, Lihua Ding, Hanghang Liu, Qian Huang, Hao Zhang, Lijuan Zhang, Jianfeng Zeng, Qiao-qian Sun, Zhen Li, Mingyuan Gao   +9 more
semanticscholar   +1 more source

Transport of molecules across tumor vasculature

CANCER AND METASTASIS REVIEW, 1987
The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined by three transport parameters (vascular permeability, P, hydraulic conductivity, Lp, and reflection coefficient, sigma); the surface area for exchange, A; and the transluminal concentration and pressure gradients.
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Perivascular nitric oxide gradients normalize tumor vasculature

Nature Medicine, 2008
Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved ...
Satoshi, Kashiwagi, Kosuke, Tsukada, Lei, Xu, Junichi, Miyazaki, Sergey V, Kozin, James A, Tyrrell, William C, Sessa, Leo E, Gerweck, Rakesh K, Jain, Dai, Fukumura   +9 more
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Tumor vasculature as target for therapeutic intervention

Expert Opinion on Investigational Drugs, 2010
Solid tumors rely on efficient oxygen and nutrients transport for their growth, development and survival. Many tumors can stimulate new blood vessel formation. Because this angiogenic vasculature is aberrant from normal host vasculature, several strategies have been explored that specifically target tumor blood vessels.Over the past decade, many ...
Fens, M.H.A.M., Storm, G., Schiffelers, R.M.   +2 more
openaire   +3 more sources