Results 261 to 270 of about 1,359,527 (294)

Studies on the Tumor Vasculature and Coagulant Microenvironment

2016
Angiogenesis represents one aspect in the complex process that leads to the generation of the vascular tumor stroma. The related functional constituents include responses of endothelial, mural, bone marrow-derived, and resident inflammatory cells as well as activation of coagulation and fibrinolytic systems in blood.
Esterina, D'Asti, Brian, Meehan, Janusz, Rak   +2 more
openaire   +2 more sources

CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges

Recent Patents on Anti-Cancer Drug Discovery, 2012
CXCL12, also known as SDF-1, is the single natural ligand for chemokine receptors CXCR4 and CXCR7. CXCL12 has angiogenic properties in normal endothelial tissue and is involved in the outgrowth and metastasis of CXCR4 expressing tumors. Recent investigations have indicated that CXCL12 levels increase after chemo- and anti- VEGF therapy, favouring ...
de NIGRIS, Filomena, Schiano C, Infante T, NAPOLI, Claudio   +3 more
openaire   +3 more sources

Targeting Tumor Vasculature: Reality or a Dream?

Journal of Drug Targeting, 2002
In recent years, it has become clear that angiogenesis is important not only in physiological processes such as embryonic development, the female reproductive cycle, wound healing, and organ and tissue regeneration but also in pathological processes such as tumor progression and metastasis (Hanahan and Folkman, 1996).
openaire   +2 more sources

Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy

2010
Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity.
Prashanth, Sreeramoju, Steven K, Libutti
openaire   +2 more sources

Transport of molecules across tumor vasculature

CANCER AND METASTASIS REVIEW, 1987
The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined by three transport parameters (vascular permeability, P, hydraulic conductivity, Lp, and reflection coefficient, sigma); the surface area for exchange, A; and the transluminal concentration and pressure gradients.
openaire   +2 more sources

Antibody Targeting of Tumor Vasculature

2002
For many years the idea of the “magic bullet” approach to target cells in the treatment of cancer and other pathological conditions has been a tempting scenario. One such approach is to develop monoclonal antibodies (MAbs) against defined cell-surface markers and use these antibodies to direct cytotoxic agents to specific cells.
J Wilson, David C West, Philip E Thorpe
openaire   +1 more source

Normalization of Tumor Vasculature and Microenvironment

2008
Solid tumors require blood vessels for growth, and many new cancer therapies are targeted against the tumor vasculature. The widely held view is that these antiangiogenic therapies destroy the tumor vasculature, thereby depriving the tumor of oxygen and nutrients. Indeed that is the ultimate goal of antiangiogenic therapies.
Rakesh K. Jain, Tracy T. Batchelor, Dan G. Duda, Christopher G. Willett   +3 more
openaire   +1 more source

Improved tumor vasculature for immunotherapy

Science, 2019
Cancer Dysfunctional vasculature in tumors reduces oxygenation and access to nutrients and prevents immune cell infiltration, which can limit immunotherapy. Cellular components of blood and lymphatic vessels can also directly modulate antitumor immune responses.
openaire   +1 more source

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1990
C H, Blood, B R, Zetter
openaire   +2 more sources

Effects of radiation on tumor vasculature

Molecular Carcinogenesis, 2022
Kristina Young, Tomoko Yamazaki
exaly