Results 241 to 250 of about 1,359,527 (294)

Spatiospectral Photoacoustic Microscopy With Gain‐Switched Ti:Sapphire Laser for High‐Accuracy Molecular Dynamics Imaging

Laser &Photonics Reviews, EarlyView.
Spatiospectral photoacoustic microscopy is enabled by stable, wavelength‐tunable dual‐pulse excitation from a gain‐switched Ti:sapphire laser. Intrinsically synchronized 532‐nm and NIR‐I pulses provide single‐scan, co‐registered mapping of oxygen saturation and indocyanine green dynamics in vivo.
Yong‐Jae Lee, Thanh Dat Le, Dong Hoon Song, Jin Hee Im, Seong‐Young Kwon, Tae Young Jeong, Jung‐Joon Min, Changho Lee, Tae Joong Eom   +8 more
wiley   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Therapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction. [PDF]

Sci Rep
Bauer N, Beckmann D, Reinhardt D, Frost N, Bobe S, Erapaneedi R, Risse B, Kiefer F.   +7 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Placental Blood‐Flow Velocity Quantification From Diffusion MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Altered placental capillary blood flow is closely linked to obstetric complications, yet quantifying capillary‐scale blood velocity remains challenging with existing imaging methods. This is partially because capillary networks form disordered microvascular beds at the voxel scale, rather than coherent, directional vessels.
ZhuangJian Yang, Diana Cruz De Oliveira, Leevi Kerkelä, Marco Palombo, Elizabeth Powell, Christopher S. Parker, Daniel Cromb, Lisa Story, Serena J. Counsell, Kelly Payette, Joseph V. Hajnal, Jana Hutter, Rebecca J. Shipley, Daniel C. Alexander, Paddy J. Slator   +14 more
wiley   +1 more source

Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy. [PDF]

Oncotarget
Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC, Yoon SS.   +6 more
europepmc   +1 more source

Deciphering plant–pathogen interaction with single‐cell omics

New Plant Protection, EarlyView.
Recent advances in single‐cell omics have enabled the decoding of gene regulatory networks at the cellular resolution during pathogen challenge. This review summarizes the technological developments in plant single‐cell omics and highlights their unique advantages for dissecting nearly all stages of plant–pathogen interactions, including initial ...
Lu Gan, Wenwen Liu, Syed S. Zaidi, Huaibing Jin   +3 more
wiley   +1 more source