Results 71 to 80 of about 4,293 (240)

Drooling as a Red Flag: Insights From a Case Series in Severe Dermatomyositis With Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Dermatomyositis (DM) is a rare idiopathic inflammatory disease characterized by progressive proximal muscle weakness and distinctive dermatologic manifestations. Although dysphagia is a recognized complication of oropharyngeal muscle involvement, drooling (sialorrhea) is infrequently described and may be a marker of severe disease.
Alireza Mirzamohamadi, Shokufe Sadeghi, Yalda Nilipour, Somayeh Motamed, Vahid Ardestani Rostami, Ahmadreza Jamshidi, Masoomeh Akhlaghi, Hoda Kavoosi, Majid Alikhani, Seyedeh Tahereh Faezi   +9 more
wiley   +1 more source

Systemic Control of Bone Homeostasis by FGF23 Signaling [PDF]

, 2016
The regulation of phosphate metabolism as an influence on bone homeostasis is profound. Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium ...
Clinkenbeard, Erica L., White, Kenneth E.   +1 more
core   +1 more source

Bone Involvement in Hyperphosphatemic Familial Tumoral Calcinosis: A New Phenotypic Presentation [PDF]

, 2021
Mutations in FGF23, KL, and GALNT3 have been identified as the cause for the development of hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC typically present in childhood or adolescence with periarticular soft tissue deposits ...
Avitan-Hersh, Emily, Bratman Morag, Sharon, Freedman, J. Daniel, Nikomarov, David, Novak, Rostislav   +4 more
core   +2 more sources

Pneumomediastinum and Pneumopericardium in Rapidly Progressive Interstitial Lung Disease Secondary to Anti‐MDA5 Dermatomyositis

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Anti‐MDA5 dermatomyositis presenting with pneumomediastinum and pneumopericardium in the setting of rapidly progressive interstitial lung disease. These air‐leak complications signal severe, uncontrolled pulmonary inflammation. Early recognition of cutaneous clues and prompt, multidisciplinary escalation of immunosuppression are critical to improving ...
Thomas Bond, Karan Kanani, Mili Pansuria, Kehinde Sunmboye   +3 more
wiley   +1 more source

Genetic diseases of renal phosphate handling [PDF]

, 2006
UNLABELLED: Renal control of systemic phosphate homeostasis is critical as evident from inborn and acquired diseases causing renal phosphate wasting. At least three transport proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1 ...
Wagner, Carsten A., Rubio-Aliaga, Isabel, Biber, Jürg, Hernando, Nati   +3 more
core   +3 more sources

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 412-424, October 2025.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Idiopathic Tumoral Calcinosis – Rare Clinico Pathological Entity: A Report of Two Cases [PDF]

Journal of Clinical and Diagnostic Research, 2017
Tumoral calcinosis is a rare disease reported mainly in blacks of tropical and subtropical African regions. It is characterized by tumour-like periarticular deposits of calcium that are found in the regions of the hip, shoulder, elbow and small joints ...
Sreedevi Jakka, Radhika Narayan, Minakshi Mishra, Farah Rana, J.K.Laik   +4 more
doaj   +1 more source

Calcinosis in juvenile dermatomyositis, a therapeutic challenge [PDF]

, 2007
Calcinosis is a common and debilitating complication of dermatomyositis. It is a hallmark of the disease, occurring mainly in pediatric patients. Little is known about its pathophysiology, and there is no universally recognized treatment.
Castro, Tânia Caroline Monteiro de, Hilário, Maria Odete Esteves, Len, Claudio Arnaldo, Terreri, Maria Teresa Ramos Ascensão, Yamashita, Edson   +4 more
core   +3 more sources

Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho [PDF]

, 2016
αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL deficiency are characterized by hyperphosphatemia and vascular calcification (VC).
Bhaskaran, Manoj, Cass, Taryn A., Clinkenbeard, Erica L., Cramer, Martin S., Hum, Julia M., Johnson, Robert L., O’Bryan, Linda M., Smith, Rosamund C., Tatiparthi, Arun K., White, Kenneth E., Wilson, Jonathan M.   +10 more
core   +1 more source

Long follow-up of Multiple Recurrent Calcific Masses–A rare case report of Hyperphosphatemic Familial Tumoral Calcinosis

Journal of University Medical & Dental College, 2022
Hyperphosphatemic familial tumoral calcinosis (HFTC) is an autosomal recessive benign condition of dysregulated phosphate metabolism (biallelic mutation in GLANT3, KLOTHO or FGF23) due to deficiency or resistance of intact fibroblast growth factor 23 ...
Saad Ahmed, Ayesha Saeed, Shafique Farooq , Zeeshan Yaqoob, Fatima tul Zohra, Muhammad Waqas   +5 more
doaj   +1 more source