Results 91 to 100 of about 396,195 (253)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Human Skin-Derived Mast Cells Spontaneously Secrete Several Angiogenesis-Related Factors

Frontiers in Immunology, 2019
Mast cells are classically recognized as cells that cause IgE-mediated allergic reactions. However, their ability to store and secrete vascular endothelial growth factor (VEGF) suggests a role in vascular development and tumorigenesis.
Cody McHale, Zahraa Mohammed, Gregorio Gomez   +2 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

RAS mutations and oncogenesis: not all RAS mutations are created equally

Frontiers in Genetics, 2012
Mutation in RAS proteins is one of the most common genetic alterations observed in human and experimentally induced rodent cancers. In vivo, oncogenic mutations have been shown to occur at exons 12, 13, and 61, resulting in any one of 19 possible point ...
Mark Steven Miller, Lance David Miller
doaj   +1 more source

Molecular tumorigenesis of the skin [PDF]

, 2014
Skin tumors are supposed to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin tumors, including benign, seborrheic keratosis, and malignant, squamous cell carcinoma and ...
10260069, Nakasuka, Ayaka, 大津, 雅信, Mizutani, Tomoya, クボ, ヨシアキ, 70314870, 水谷, 友哉, 福井, 眺万, Oshima, Mika, ムラオ, カズトシ, Murao, Kazutoshi, 533, Sogawa, Maiko, 久保, 宜明, 40363171, 松立, 吉弘, ソガワ, マイコ, 大島, 三佳, 1539, ミズタニ, トモヤ, Hashimoto, Ichiro, フクイ, ノゾミ, ナカスカ, アヤカ, 村尾, 和俊, 60055/profile-ja.html, 1198, 80622729, ハシモト, イチロウ, マツダテ, ヨシヒロ, 橋本, 一郎, Fukui, Nozomi, 中須賀, 彩香, Matsudate, Yoshihiro, 1621, Kubo, Yoshiaki, オオシマ, ミカ, オオツ, マサノブ, 70556/profile-ja.html, Otsu, Masanobu, 60221/profile-ja.html   +39 more
core  

STAT1 and STAT3 in tumorigenesis [PDF]

, 2012
The transcription factors STAT1 and STAT3 appear to play opposite role in tumorigenesis. While STAT3 propmotes survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers antiproliferative and pro ...
Francesco Novelli, Valeria Poli, Regis, Gabriella, Sara Pensa, Lidia Avalle, Poli, Valeria, Pensa S., Gabriella Regis, Novelli, Francesco, Avalle, Lidia   +9 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer

Advanced Science
Although a fraction of functional peptides concealed within long non‐coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA‐encoded peptides are involved in the malignancy of cervical cancer (CC).
Xiaoyu Qi, Jing Zhou, Xinyue Wang, Yan Shen, Yuxun Cao, Liangzi Jiang, Miaomiao Shen, Haoran Zhang, Tianjiao Wang, Pengjun Wei, Ruoqi Xu, Yue Yang, Xiangya Ding, Cong Wang, Xuemei Jia, Qin Yan, Wan Li, Chun Lu   +17 more
doaj   +1 more source

The Role of Ferroptosis in Cancer Development and Treatment Response

Frontiers in Pharmacology, 2018
Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell death, which is a distinct regulated cell death comparing to other cell death.
Bin Lu, Xiao Bing Chen, Mei Dan Ying, Qiao Jun He, Ji Cao, Bo Yang   +5 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source