Results 81 to 90 of about 396,195 (253)
Vagotomy and Gastric Tumorigenesis [PDF]
, 2016 Vagotomy reduces gastric acid secretion and was therefore introduced as a surgical treatment for peptic ulcers in the 1970s. Later, it was replaced by acid reducing medication, such as histamine type 2 (H2) receptor antagonists and proton pump inhibitors
Chen, Duan +4 more
core +2 more sources
, 2018 Zhengyi Ruan, Xingyu Yang, Weiwei Cheng Department of Obstetrics and Gynaecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Background: Although surgery, chemotherapy, and ...
Yang X, Ruan Z, Cheng W
core
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Gene regulation and tumorigenesis in transgenic mice.
, 1988 Gene regulation and tumorigenesis in transgenic ...
Yongwon. Choi (7989953)
core +5 more sources
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis
EXCLI Journal : Experimental and Clinical SciencesThe significance of ERK1/2 in the process of tumorigenesis has attracted considerable interest owing to its essential role in a variety of cellular mechanisms, especially in relation to cancer initiation and progression.
Jiaying Fei, Yanjun Guo
doaj +1 more source
Frontiers in Pharmacology, 2018 Long non-coding RNA (LncRNA) actin filament-associated protein1-antisense RNA 1 (AFAP1-AS1) is overexpressed in various types of cancers and plays an important role in tumor progression and prognosis.
Kaiming Zhang +7 more
doaj +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis
, 2016 Cell cycle genes are often aberrantly expressed in cancer, but how their misexpression drives tumorigenesis mostly remains unclear. From S phase to early mitosis, EMI1 (also known as FBXO5) inhibits the anaphase-promoting complex/cyclosome, which ...
Cato, K +13 more
core +1 more source
SLC5A8 and its role in tumorigenesis [PDF]
, 2011 Deep insight on SLC5A8 and its role in ...
Rhoden, KJ, RHODEN, KERRY JANE
core +1 more source