Results 221 to 230 of about 504,448 (294)
SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics
Advanced Science, EarlyView.ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao +11 more
wiley +1 more source
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets. [PDF]
MedComm (2020)Liu X, Wang Z, Zhu H, Han Y, Ji Q.
europepmc +1 more source
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang +16 more
wiley +1 more source
Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. [PDF]
World J Gastrointest OncolLin X, Lin GF, Gu FT, Li YL.
europepmc +1 more source
Advanced Science, EarlyView.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Novel N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) writer METTL16 promotes the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis. [PDF]
Discov OncolHuang Z, Luo Y, Gao Q, Wang L, Li C.
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence. [PDF]
OncogenesisHe S +5 more
europepmc +1 more source