Results 221 to 230 of about 527,270 (344)

Deletion of cytosolic phospholipase A ₂ suppresses Apc ^Min -induced tumorigenesis

, 2001
Karen Hong, Joanna C. Bonventre, Eileen O’Leary, Joseph V. Bonventre, Eric S. Lander   +4 more
openalex   +2 more sources

Pituitary Tumor-Transforming Gene: Physiology and Implications for Tumorigenesis [PDF]

, 2007
George Vlotides, Tamar Eigler, Шломо Мелмед   +2 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Data from A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis

, 2023
Élisabeth Rémy, Sandra Rebouissou, Claudine Chaouiya, Andreï Zinovyev, François Radvanyi, Laurence Calzone   +5 more
openalex   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat. [PDF]

Cancer Discov
Shepard A, Lester DK, Troutman S, Hoxha S, Khaled WT, Smith ESJ, Park TJ, Buffenstein R, Du D, Teng M, Dengler-Crish CM, Tsai KY, Flores ER, Ventura A, Kissil JL.   +14 more
europepmc   +1 more source

Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells [PDF]

, 2012
Ke‐Hung Tsui, Ying‐Ling Chang, Tsui‐Hsia Feng, Li‐Chuan Chung, Tzu‐Yi Lee, Phei‐Lang Chang, Horng‐Heng Juang   +6 more
openalex   +1 more source

Supplemental Figure. 4 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

, 2023
Kimita Suyama, Jiahong Yao, Huizhi Liang, Outhiriaradjou Benard, Olivier Loudig, Dulguun Amgalan, Wendy M. McKimpson, Greg R. Phillips, Jeffrey E. Segall, Yihong Wang, Susan Fineberg, Larry Norton, Richard N. Kitsis, Rachel B. Hazan   +13 more
openalex   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis. [PDF]

Hum Genomics
Marvalim C, Chan DKH.
europepmc   +1 more source