Results 231 to 240 of about 320,341 (266)
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Aneuploidy and tumorigenesis in Drosophila
Seminars in Cell & Developmental Biology, 2014Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated.
Milán, Marco +3 more
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2007
A hallmark of mature B-cell lymphomas is reciprocal chromosomal translocations involving the Ig locus and a proto-oncogene, which usually result in the deregulated, constitutive expression of the translocated gene. In addition to such translocations, proto-oncogenes are frequently hypermutated in germinal center (GC)-derived B-cell lymphomas.
Il-mi, Okazaki +2 more
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A hallmark of mature B-cell lymphomas is reciprocal chromosomal translocations involving the Ig locus and a proto-oncogene, which usually result in the deregulated, constitutive expression of the translocated gene. In addition to such translocations, proto-oncogenes are frequently hypermutated in germinal center (GC)-derived B-cell lymphomas.
Il-mi, Okazaki +2 more
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Tumorigenesis: it takes a village
Nature Reviews Cancer, 2015Although it is widely accepted that most cancers exhibit some degree of intratumour heterogeneity, we are far from understanding the dynamics that operate among subpopulations within tumours. There is growing evidence that cancer cells behave as communities, and increasing attention is now being directed towards the cooperative behaviour of subclones ...
Doris P, Tabassum, Kornelia, Polyak
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CRC Critical Reviews in Toxicology, 1976
This review deals with factors and mechanisms involved in sarcoma development upon implantation of chemically inert foreign bodies. The topic is of importance regarding cancer in asbestosis or schistosomiasis, and also in view of increasing ise of artificial implants.
K. Gerhard Brand +3 more
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This review deals with factors and mechanisms involved in sarcoma development upon implantation of chemically inert foreign bodies. The topic is of importance regarding cancer in asbestosis or schistosomiasis, and also in view of increasing ise of artificial implants.
K. Gerhard Brand +3 more
openaire +2 more sources
Autophagy and Tumorigenesis in Drosophila
2019The resurgence of Drosophila as a recognized model for carcinogenesis has contributed greatly to our conceptual advance and mechanistic understanding of tumor growth in vivo. With its powerful genetics, Drosophila has emerged as a prime model organism to study cell biology and physiological functions of autophagy.
Rojyar, Khezri, Tor Erik, Rusten
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Mechanisms of Viral Tumorigenesis
1982Publisher Summary The mechanism or mechanisms by which viruses cause tumors represents a complex in vivo problem. The interactions of viruses such as simian virus 40 (SV40) and Rous sarcoma virus (RSV) with sensitive target cells have shown that integration into host cell DNA of specific viral genes is essential for initiation of cellular ...
R V, Gilden, H, Rabin
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Preneoplasia in mammary tumorigenesis
1996It is axiomatic that cancers in epithelial organs arise via multiple intermediate stages. This concept is termed multistage carcinogenesis and is based upon both clinical and experimental observations over the past 40 years in practically all major epithelial organs [1–3].
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Adhesion-GPCRs in Tumorigenesis
2010Tumor growth is a highly complex, multistep process that involves tumor cell detachment, migration, invasion and metastasis accompanied by angiogenesis and extracellular matrix turn-over. Each of the steps is influenced by tumor cell interaction and interaction of the tumor cell with its microenvironment that consists of different cell types as tumor ...
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Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis
Cell, 2020Ana Veloso +2 more
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