Results 251 to 260 of about 393,410 (301)
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Annals of the New York Academy of Sciences, 2006
Abstract: Through the widespread use of imaging techniques with great sensitivity adrenal tumors are often diagnosed as an incidental finding. Although the majority of these adrenal lesions are benign and without evidence of endocrine activity or malignancy, hormone hypersecretion needs to be ruled out by specific tests.
Beuschlein, Felix, Reincke, Martin
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Abstract: Through the widespread use of imaging techniques with great sensitivity adrenal tumors are often diagnosed as an incidental finding. Although the majority of these adrenal lesions are benign and without evidence of endocrine activity or malignancy, hormone hypersecretion needs to be ruled out by specific tests.
Beuschlein, Felix, Reincke, Martin
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2020
Tumour cells are derived from normal cells that undergo numerous genetic and epigenetic mutations under various stresses. This process involves changes in many intrinsic cellular mechanisms and in the microenvironment. Understanding the process is important for preventing tumorigenesis and tumour recurrence.
Wenting, Liu +4 more
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Tumour cells are derived from normal cells that undergo numerous genetic and epigenetic mutations under various stresses. This process involves changes in many intrinsic cellular mechanisms and in the microenvironment. Understanding the process is important for preventing tumorigenesis and tumour recurrence.
Wenting, Liu +4 more
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Current Pharmaceutical Biotechnology, 2007
Emerging evidence suggests a class of non-coding RNAs termed microRNAs (miRNAs) play a key role in cancer. Since their original discovery in C. elegans in 1993 it has become evident that miRNAs are responsible for an entirely new mechanism of post-transcriptional gene regulation.
Kai Ove, Skaftnesmo +3 more
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Emerging evidence suggests a class of non-coding RNAs termed microRNAs (miRNAs) play a key role in cancer. Since their original discovery in C. elegans in 1993 it has become evident that miRNAs are responsible for an entirely new mechanism of post-transcriptional gene regulation.
Kai Ove, Skaftnesmo +3 more
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Oncology, 2009
A single dose of cadmium chloride (CdCl<sub>2</sub>) (0.02–0.03 mM/kg) given subcutaneously to mature male Wistar rats leads to rapid testicular necrosis and, subsequently, to the development of interstitial cell neoplasms. Testicular tissue containing these neoplasms transforms labeled progesterone in vitro to testosterone, but this ...
O J, Lucis, R, Lucis, K, Aterman
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A single dose of cadmium chloride (CdCl<sub>2</sub>) (0.02–0.03 mM/kg) given subcutaneously to mature male Wistar rats leads to rapid testicular necrosis and, subsequently, to the development of interstitial cell neoplasms. Testicular tissue containing these neoplasms transforms labeled progesterone in vitro to testosterone, but this ...
O J, Lucis, R, Lucis, K, Aterman
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Cancer Letters, 2003
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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Hormone Research, 2008
Thyroid tumorigenesis is discussed in the context of the thyroid as a stable tissue, composed of differentiated cells, with a greater dissociation of control of growth from control of differentiation than is found in stem cell tissues. Experimental thyroid carcinogenesis regimes usually use mutagen exposure followed by induced growth.
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Thyroid tumorigenesis is discussed in the context of the thyroid as a stable tissue, composed of differentiated cells, with a greater dissociation of control of growth from control of differentiation than is found in stem cell tissues. Experimental thyroid carcinogenesis regimes usually use mutagen exposure followed by induced growth.
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Frontiers in Bioscience - Landmark, 2017 Functional genomics studies over the past decades have unveiled that the human genome transcribes a large amount of long noncoding RNAs (lncRNAs) which have been implicated in regulation of diverse cellular functions. Dysregulation of lncRNAs are often associated with human diseases including cancer.
Wan-Xin Peng +2 more
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Phosphatases and tumorigenesis
Current Opinion in Oncology, 1998Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind.
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Annals of the New York Academy of Sciences, 2007
Abstract: The role of parathyroid hormone‐related peptide (PTHrP) in the regulation of hypercalcemia in patients with malignancies is well studied, but whether its expression in tumor tissue correlates with tumor progression is not clear at present.
Minoru, Nishihara +3 more
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Abstract: The role of parathyroid hormone‐related peptide (PTHrP) in the regulation of hypercalcemia in patients with malignancies is well studied, but whether its expression in tumor tissue correlates with tumor progression is not clear at present.
Minoru, Nishihara +3 more
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