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Contributions of Myc to tumorigenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [
Werner, Lutz +2 more
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Inflammation and liver tumorigenesis
Frontiers of Medicine, 2013Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including
Beicheng, Sun, Michael, Karin
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Epigenetic Mechanisms of Tumorigenesis
Hormone and Metabolic Research, 2005In the majority of human cancers, heritable loss of gene function through cell division may be mediated as often by epigenetic as by genetic abnormalities. Epigenetic modification occurs through a process of interrelated changes in CpG island methylation and histone modifications. Candidate gene approaches of cell cycle, growth regulatory and apoptotic
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Tumorigenesis: it takes a village
Nature Reviews Cancer, 2015Although it is widely accepted that most cancers exhibit some degree of intratumour heterogeneity, we are far from understanding the dynamics that operate among subpopulations within tumours. There is growing evidence that cancer cells behave as communities, and increasing attention is now being directed towards the cooperative behaviour of subclones ...
Doris P, Tabassum, Kornelia, Polyak
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Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1970
SV40‐transformed cell lines from 8 kidneys and 2 embryos of inbread CBA mice were grown in vitro and repeatedly tested for oncogenicity in adult syngeneic hosts by subcutaneous inoculation of about 50 × 106 cells. In contrast to spontaneously developing permanent mouse embryo lines, these in vitro lines never induced any progressive tumours.
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SV40‐transformed cell lines from 8 kidneys and 2 embryos of inbread CBA mice were grown in vitro and repeatedly tested for oncogenicity in adult syngeneic hosts by subcutaneous inoculation of about 50 × 106 cells. In contrast to spontaneously developing permanent mouse embryo lines, these in vitro lines never induced any progressive tumours.
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CRC Critical Reviews in Toxicology, 1976
This review deals with factors and mechanisms involved in sarcoma development upon implantation of chemically inert foreign bodies. The topic is of importance regarding cancer in asbestosis or schistosomiasis, and also in view of increasing ise of artificial implants.
K. Gerhard Brand +3 more
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This review deals with factors and mechanisms involved in sarcoma development upon implantation of chemically inert foreign bodies. The topic is of importance regarding cancer in asbestosis or schistosomiasis, and also in view of increasing ise of artificial implants.
K. Gerhard Brand +3 more
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Alpha-Crystallins and Tumorigenesis
Current Molecular Medicine, 2012αA- and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract ...
P, Chen +15 more
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Autophagy and Tumorigenesis in Drosophila
2019The resurgence of Drosophila as a recognized model for carcinogenesis has contributed greatly to our conceptual advance and mechanistic understanding of tumor growth in vivo. With its powerful genetics, Drosophila has emerged as a prime model organism to study cell biology and physiological functions of autophagy.
Rojyar, Khezri, Tor Erik, Rusten
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Mechanisms of Viral Tumorigenesis
1982Publisher Summary The mechanism or mechanisms by which viruses cause tumors represents a complex in vivo problem. The interactions of viruses such as simian virus 40 (SV40) and Rous sarcoma virus (RSV) with sensitive target cells have shown that integration into host cell DNA of specific viral genes is essential for initiation of cellular ...
R V, Gilden, H, Rabin
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Adhesion-GPCRs in Tumorigenesis
2010Tumor growth is a highly complex, multistep process that involves tumor cell detachment, migration, invasion and metastasis accompanied by angiogenesis and extracellular matrix turn-over. Each of the steps is influenced by tumor cell interaction and interaction of the tumor cell with its microenvironment that consists of different cell types as tumor ...
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