Results 221 to 230 of about 320,341 (266)
Some of the next articles are maybe not open access.
Oncology, 2009
A single dose of cadmium chloride (CdCl<sub>2</sub>) (0.02–0.03 mM/kg) given subcutaneously to mature male Wistar rats leads to rapid testicular necrosis and, subsequently, to the development of interstitial cell neoplasms. Testicular tissue containing these neoplasms transforms labeled progesterone in vitro to testosterone, but this ...
O J, Lucis, R, Lucis, K, Aterman
openaire +2 more sources
A single dose of cadmium chloride (CdCl<sub>2</sub>) (0.02–0.03 mM/kg) given subcutaneously to mature male Wistar rats leads to rapid testicular necrosis and, subsequently, to the development of interstitial cell neoplasms. Testicular tissue containing these neoplasms transforms labeled progesterone in vitro to testosterone, but this ...
O J, Lucis, R, Lucis, K, Aterman
openaire +2 more sources
Current Pharmaceutical Biotechnology, 2007
Emerging evidence suggests a class of non-coding RNAs termed microRNAs (miRNAs) play a key role in cancer. Since their original discovery in C. elegans in 1993 it has become evident that miRNAs are responsible for an entirely new mechanism of post-transcriptional gene regulation.
Kai Ove, Skaftnesmo +3 more
openaire +2 more sources
Emerging evidence suggests a class of non-coding RNAs termed microRNAs (miRNAs) play a key role in cancer. Since their original discovery in C. elegans in 1993 it has become evident that miRNAs are responsible for an entirely new mechanism of post-transcriptional gene regulation.
Kai Ove, Skaftnesmo +3 more
openaire +2 more sources
Cancer Letters, 2003
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
openaire +2 more sources
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
openaire +2 more sources
Hormone Research, 2008
Thyroid tumorigenesis is discussed in the context of the thyroid as a stable tissue, composed of differentiated cells, with a greater dissociation of control of growth from control of differentiation than is found in stem cell tissues. Experimental thyroid carcinogenesis regimes usually use mutagen exposure followed by induced growth.
openaire +2 more sources
Thyroid tumorigenesis is discussed in the context of the thyroid as a stable tissue, composed of differentiated cells, with a greater dissociation of control of growth from control of differentiation than is found in stem cell tissues. Experimental thyroid carcinogenesis regimes usually use mutagen exposure followed by induced growth.
openaire +2 more sources
Phosphatases and tumorigenesis
Current Opinion in Oncology, 1998Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind.
openaire +2 more sources
Annals of the New York Academy of Sciences, 2007
Abstract: The role of parathyroid hormone‐related peptide (PTHrP) in the regulation of hypercalcemia in patients with malignancies is well studied, but whether its expression in tumor tissue correlates with tumor progression is not clear at present.
Minoru, Nishihara +3 more
openaire +2 more sources
Abstract: The role of parathyroid hormone‐related peptide (PTHrP) in the regulation of hypercalcemia in patients with malignancies is well studied, but whether its expression in tumor tissue correlates with tumor progression is not clear at present.
Minoru, Nishihara +3 more
openaire +2 more sources
Contributions of Myc to tumorigenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [
Werner, Lutz +2 more
openaire +2 more sources
Centrosome amplification in tumorigenesis
Cancer Letters, 2012With regard to cancer development the centrosome has been the center of attraction of scientists for already more than a 100 years. After the initial assumption that amplified centrosomes and abnormal mitotic arrangements might be a cause of cancer at the beginning of the last century, enormous efforts have been undertaken to clarify the relevance of ...
Simon J, Anderhub +2 more
openaire +2 more sources
Tumorigenesis and the angiogenic switch
Nature Reviews Cancer, 2003It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and ...
Gabriele, Bergers, Laura E, Benjamin
openaire +2 more sources
Epigenetic Mechanisms of Tumorigenesis
Hormone and Metabolic Research, 2005In the majority of human cancers, heritable loss of gene function through cell division may be mediated as often by epigenetic as by genetic abnormalities. Epigenetic modification occurs through a process of interrelated changes in CpG island methylation and histone modifications. Candidate gene approaches of cell cycle, growth regulatory and apoptotic
openaire +2 more sources