Results 221 to 230 of about 490,488 (261)

Necroptosis pathways in tumorigenesis

Seminars in Cancer Biology, 2022
Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer.
Tao, Zhang, Yingnan, Wang, Hiroyuki, Inuzuka, Wenyi, Wei   +3 more
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Contributions of Myc to tumorigenesis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [
Werner, Lutz, Javier, Leon, Martin, Eilers   +2 more
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Centrosome amplification in tumorigenesis

Cancer Letters, 2012
With regard to cancer development the centrosome has been the center of attraction of scientists for already more than a 100 years. After the initial assumption that amplified centrosomes and abnormal mitotic arrangements might be a cause of cancer at the beginning of the last century, enormous efforts have been undertaken to clarify the relevance of ...
Simon J, Anderhub, Alwin, Krämer, Bettina, Maier   +2 more
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Epigenetic Mechanisms of Tumorigenesis

Hormone and Metabolic Research, 2005
In the majority of human cancers, heritable loss of gene function through cell division may be mediated as often by epigenetic as by genetic abnormalities. Epigenetic modification occurs through a process of interrelated changes in CpG island methylation and histone modifications. Candidate gene approaches of cell cycle, growth regulatory and apoptotic
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Tumorigenesis and the angiogenic switch

Nature Reviews Cancer, 2003
It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and ...
Gabriele, Bergers, Laura E, Benjamin
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Aneuploidy and tumorigenesis in Drosophila

Seminars in Cell & Developmental Biology, 2014
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated.
Milán, Marco, Clemente-Ruiz, Marta, Dekanty, Andres, Muzzopappa, Mariana   +3 more
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Role of AID in Tumorigenesis

2007
A hallmark of mature B-cell lymphomas is reciprocal chromosomal translocations involving the Ig locus and a proto-oncogene, which usually result in the deregulated, constitutive expression of the translocated gene. In addition to such translocations, proto-oncogenes are frequently hypermutated in germinal center (GC)-derived B-cell lymphomas.
Il-mi, Okazaki, Ai, Kotani, Tasuku, Honjo   +2 more
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Alpha-Crystallins and Tumorigenesis

Current Molecular Medicine, 2012
αA- and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract ...
P, Chen, W, Ji, F-Y, Liu, H-Z, Tang, S, Fu, X, Zhang, M, Liu, L, Gong, M, Deng, W-F, Hu, X-H, Hu, X-W, Chen, Z-L, Li, X, Li, J, Liu, D W-C, Li   +15 more
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Preneoplasia in mammary tumorigenesis

1996
It is axiomatic that cancers in epithelial organs arise via multiple intermediate stages. This concept is termed multistage carcinogenesis and is based upon both clinical and experimental observations over the past 40 years in practically all major epithelial organs [1–3].
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Adhesion-GPCRs in Tumorigenesis

2010
Tumor growth is a highly complex, multistep process that involves tumor cell detachment, migration, invasion and metastasis accompanied by angiogenesis and extracellular matrix turn-over. Each of the steps is influenced by tumor cell interaction and interaction of the tumor cell with its microenvironment that consists of different cell types as tumor ...
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