Results 51 to 60 of about 155,806 (387)
Molecular Therapy: Methods & Clinical Development, 2017 Human pluripotent stem cells (hPSCs) are a promising source of regenerative material for clinical applications. However, hPSC transplant therapies pose the risk of teratoma formation and malignant transformation of undifferentiated remnants.
Kaoru Mitsui +3 more
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Frontiers in Cell and Developmental Biology, 2021 Our studies have demonstrated that cell tumorigenicity and pluripotent differentiation potential stem from neural stemness or a neural ground state, which is defined by a regulatory network of higher levels of machineries for basic cell physiological ...
Xiaoli Yang +16 more
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High fat diet enhances stemness and tumorigenicity of intestinal progenitors
Nature, 2016 Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine ...
Semir Beyaz +27 more
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Neural stemness contributes to cell tumorigenicity
Cell & Bioscience, 2020 Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells.
Liyang Xu +7 more
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Molecules, 2017 The use of human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) in regenerative medicine is hindered by their tumorigenic potential.
Hiroaki Tateno +2 more
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Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]
, 2018 Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S +7 more
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ST2 and Multimarker Testing in Acute Decompensated Heart Failure [PDF]
, 2015 Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge.
Antoni, Md +7 more
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Tumorigenicity Assay in Nude Mice [PDF]
BIO-PROTOCOL, 2017 Tumorigenicity refers to the ability of cultured cells to develop viable tumors in immune-deficient animals. The goal of this protocol is to illustrate tumorigenicity assay by subcutaneous tumor-cell-transplantation in nude mice. Target cells are transplanted to 6-week-old nude mice subcutaneously and the tumor growth is monitored over a period of ...
Feng Du, Xiaodi Zhao, Daiming Fan
openaire +3 more sources
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
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Cancer Management and Research, 2020 Feng Rong, Liang Liu, Can Zou, Jing Zeng, Yasheng Xu Department of Respiratory, Xiantao First People’s Hospital Affiliated to Changjiang University, Xiantao, Hubei, People’s Republic of ChinaCorrespondence: Yasheng Xu Tel +86 728-3220705Email
Rong F, Liu L, Zou C, Zeng J, Xu Y
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