Results 41 to 50 of about 13,396 (145)

The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells

Frontiers in Oncology, 2020
BackgroundDeregulation of HER2 expression could affect the biological characteristics of gastric cancer cells and treatment option for gastric cancer patients.
Li-Fei Sun, Kun Yang, Yi-Gao Wang, Yu-Xin Liu, Pei-Xian Hou, Zheng-Hao Lu, Xiao-Long Chen, Wei-Han Zhang, Zong-Guang Zhou, Xian-Ming Mo, Jian-Kun Hu   +10 more
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Tumorigenicity of a combination of psoriasis therapies [PDF]

British Journal of Cancer, 1994
Coal tar, a tumour initiator, and dithranol, a tumour promoter, are used in the treatment of psoriasis. Topical treatment of mice with pharmaceutical formulations of these two agents, at therapeutic doses, induced skin papillomas in a classical two-stage carcinogenesis protocol, while treatment with either agent alone did not.
D H, Phillips, A J, Alldrick
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GALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts

Frontiers in Oncology, 2020
Colorectal cancer (CRC)-associated senescent fibroblasts may play a crucial role in tumor progression, but the mechanism remains unclear. In order to solve this complicated problem, we randomly collected 16 patients with CRC, who had been treated with ...
Mengdi Yang, Zhiyuan Jiang, Guangyu Yao, Zhiyu Wang, Jing Sun, Huanlong Qin, Hui Zhao   +6 more
doaj   +1 more source

The tumorigenic function of LINC00858 in cancer

Biomedicine & Pharmacotherapy, 2021
Long non-coding RNA (lncRNA) plays an important regulatory role in the occurrence and development of human cancer. LINC00858 is a newly discovered lncRNA with a length of 2685 nucleotides. Existing studies have shown that LINC00858 has abnormally high expression levels in malignant tumors such as colorectal cancer, gastric cancer, hepatocellular ...
Qiudan, Zhang, Chenming, Zhong, Shiwei, Duan   +2 more
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Activation of Hepatocyte Growth Factor-Met Autocrine Loop Enhances Tumorigenicity in a Human Lung Adenocarcinoma Cell Line

Neoplasia: An International Journal for Oncology Research, 2000
Hepatocyte growth factor (HGF) is a multifunctional cytokine with effects on the proliferation, motility, and differentiation of cells that express its receptor Met.
Seung Yi, Ming-Sound Tsao
doaj   +1 more source

An AOP-Based Integrated In Vitro and In Vivo Assessment of the Non-Genotoxic Carcinogenic Potential of Multi-Walled Carbon Nanotubes

Nanomaterials
Multi-walled carbon nanotubes (MWCNTs) are increasingly incorporated into industrial and consumer products, raising concerns about potential carcinogenicity because their physicochemical properties vary widely among materials.
Minju Kim, Heesung Hwang, Sulhwa Song, Keun-Soo Kim, JuHee Lee, Seung Min Oh   +5 more
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Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma

Emerging Microbes and Infections, 2022
Hepatitis B virus (HBV) exists as quasispecies (QS). However, the evolutionary characteristics of haplotypes of HBV X gene in the hepatocellular carcinoma (HCC) microenvironment remain unclear. Mutations across X gene are essential for the tumorigenicity
Ya Fu, Fengling Fang, Hongyan Guo, Xialin Xiao, Yuhai Hu, Yongbin Zeng, Tianbin Chen, Songhang Wu, Ni Lin, Jinlan Huang, Ling Jiang, Qishui Ou, Can Liu   +12 more
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Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling

Animal Cells and Systems, 2021
Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula, Yating Su, Dilixiati Tuniyazi, Chao Yi   +3 more
doaj   +1 more source

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
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Senescence and the Pro-tumorigenic Stroma [PDF]

Critical Reviews in Oncogenesis, 2013
Hayflick and Moorhead first described senescence in the late 1960's as a permanent growth arrest that primary cells underwent after a defined number of cellular divisions in culture. This observation gave rise to the hypothesis that cells contained an internal counting mechanism that limited cellular division and that this limit was an important ...
Elise, Alspach, Yujie, Fu, Sheila A, Stewart   +2 more
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