Results 61 to 70 of about 155,806 (387)

Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma

Emerging Microbes and Infections, 2022
Hepatitis B virus (HBV) exists as quasispecies (QS). However, the evolutionary characteristics of haplotypes of HBV X gene in the hepatocellular carcinoma (HCC) microenvironment remain unclear. Mutations across X gene are essential for the tumorigenicity
Ya Fu, Fengling Fang, Hongyan Guo, Xialin Xiao, Yuhai Hu, Yongbin Zeng, Tianbin Chen, Songhang Wu, Ni Lin, Jinlan Huang, Ling Jiang, Qishui Ou, Can Liu   +12 more
doaj   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma

Frontiers in Molecular Biosciences, 2023
Background: GGPS1(geranylgeranyl diphosphate synthase 1) is a member of the prenyltransferase family. Abnormal expression of GGPS1 can disrupt the balance between protein farnesylation and geranylgeranylation, thereby affecting a variety of cellular ...
Ke Huang, Ke Huang, Liang Han, Huimei Xu, Ruiming Xu, Hao Guo, Huihui Wang, Zhaoqing Xu   +7 more
doaj   +1 more source

Spontaneous DNA damage propels tumorigenicity [PDF]

Cell Research, 2017
High levels of endogenously generated DNA damage drive oncogenesis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additional insights into this topic by uncovering a novel intrinsic source of double-strand breaks that fosters the aggressiveness and stemness of ...
Ilio, Vitale, Guido, Kroemer
openaire   +2 more sources

Somatic gene therapy for cancer. The utility of transferrinfection in generating ‘tumor vaccines’ [PDF]

, 1993
The last few years have seen the development of a branch of somatic gene therapy which aims at strengthening the immune surveillance of the body, leading to eradication of disseminated cancer tumor cells and occult micrometastases after surgical removal ...
Aoki, Asher, Blankenstein, Bohle, Bubenik, Chen, Cloudman, Colombo, Cotten, Curiel, Dorsch, Dranoff, Ernst Wagner, Esumi, Fearon, Fearon, Gansbacher, Gansbacher, Georg Stingl, Golumbek, Groen, Hock, Hock, Itaya, Ito, Janeway, Kenne, Kurt Zatloukal, Kushtai, Lake, Lake, Lehner, Ley, Liebrich, Lindenmann, Linsley, Lurquin, Maraguchi, Matthew Cotten, Max L. Birnstiel, Nossal, Ohe, Ostrand-Rosenberg, Pardoll, Plaksin, Porgador, Restifo, Rollins, Roth, Russell, Schwartz, Tepper, Tepper, Townsend, Van der Bruggen, Van Pel, Wagner, Wallack, Walter Schmidt, Watanabe, Zatloukal   +60 more
core   +1 more source

Novel miR-5088-5p promotes malignancy of breast cancer by inhibiting DBC2

Molecular Therapy: Nucleic Acids, 2021
Breast cancer is the most common female cancer in the world. Despite the active research on metastatic breast cancer, the treatment of breast cancer patients is still difficult because the mechanism is not well known.
Hyun Jeong Seok, Young Eun Choi, Jae Yeon Choi, Joo Mi Yi, Eun Joo Kim, Mi Young Choi, Su-Jae Lee, In Hwa Bae   +7 more
doaj   +1 more source

Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]

, 2015
Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee, Coleman, Rosalind A., Garcia Fabiani, Maria Belen, Gonzalez-Baró, Lacunza, Ezequiel, Montanaro, Mauro Aldo, Pellon Maison, Magali   +6 more
core   +2 more sources

The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells

Frontiers in Oncology, 2020
BackgroundDeregulation of HER2 expression could affect the biological characteristics of gastric cancer cells and treatment option for gastric cancer patients.
Li-Fei Sun, Kun Yang, Yi-Gao Wang, Yu-Xin Liu, Pei-Xian Hou, Zheng-Hao Lu, Xiao-Long Chen, Wei-Han Zhang, Zong-Guang Zhou, Xian-Ming Mo, Jian-Kun Hu   +10 more
doaj   +1 more source

TGF‐β‐activated lncRNA LINC00115 is a critical regulator of glioma stem‐like cell tumorigenicity

EMBO Reports, 2019
Long non‐coding RNAs (lncRNAs) are critical regulators in cancer. However, the involvement of lncRNAs in TGF‐β‐regulated tumorigenicity is still unclear. Here, we identify TGF‐β‐activated lncRNA LINC00115 as a critical regulator of glioma stem‐like cell (
Jianming Tang, Bo Yu, Yanxin Li, Weiwei Zhang, A. Alvarez, Bo Hu, Shi-Yuan Cheng, Haizhong Feng   +7 more
semanticscholar   +1 more source

Activation of Hepatocyte Growth Factor-Met Autocrine Loop Enhances Tumorigenicity in a Human Lung Adenocarcinoma Cell Line

Neoplasia: An International Journal for Oncology Research, 2000
Hepatocyte growth factor (HGF) is a multifunctional cytokine with effects on the proliferation, motility, and differentiation of cells that express its receptor Met.
Seung Yi, Ming-Sound Tsao
doaj   +1 more source