Results 71 to 80 of about 66,124 (248)

Supplementary methods from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

, 2023
Luca d’Agostino, Yingchao Nie, Sayantani Goswami, Kevin Tong, Shiyan Yu, Sheila Bandyopadhyay, J. Casado Flores, Xiao Zhang, Iyshwarya Balasubramanian, Ivor Joseph, Ryotaro Sakamori, Victoria Farrell, Qi Li, Chung S. Yang, Bin Gao, Ronaldo P. Ferraris, Ghassan Yehia, Edward M. Bonder, James R. Goldenring, Michael P. Verzi, Lanjing Zhang, Y. Tony Ip, Nan Gao   +22 more
openalex   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas

Stem Cell Reports, 2016
The use of cells derived from pluripotent stem cells (PSCs) for regenerative therapies confers a considerable risk for neoplastic growth and teratoma formation.
Johannes Riegler, Antje Ebert, Xulei Qin, Qi Shen, Mouer Wang, Mohamed Ameen, Kazuki Kodo, Sang-Ging Ong, Won Hee Lee, Grace Lee, Evgenios Neofytou, Joseph D. Gold, Andrew J. Connolly, Joseph C. Wu   +13 more
doaj   +1 more source

Supplementary Figure 3 from Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas

, 2023
Liping Liu, Kun Chen, Jueheng Wu, Ling Shi, Bo Hu, Shi‐Yuan Cheng, Mengfeng Li, Libing Song   +7 more
openalex   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Characteristics of Stem Cells from Human Neuroblastoma Cell Lines and in Tumors

Neoplasia: An International Journal for Oncology Research, 2004
Cellular heterogeneity is a hallmark of human neuroblastoma tumors and cell lines. Within a single neuroblastoma are cells from distinct neural crest lineages whose relative abundance is significant for prognosis.
Jeanette D. Walton, David R. Kattan, Sharon K. Thomas, Barbara A. Spengler, Hong-Fen Guo, June L. Biedler, Nai-Kong V. Cheung, Robert A. Ross   +7 more
doaj   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Supplementary Figure S5 from CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

, 2023
Samantha E. Boyle, Clare G. Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard Young, Annie Wong, Robert Fuller, J. D. Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A. Henderson, Ricky W. Johnstone, Anthony T. Papenfuss, Mark Shackleton   +17 more
openalex   +1 more source