Results 151 to 160 of about 5,905,711 (364)

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen. [PDF]

, 1990
Breaking the state of immunological unresponsiveness of tumor-bearing individuals to cancer is a prerequisite for active or passive tumor-specific immunotherapy.
Koeppen, H, Perdrizet, GA, Ross, SR, Schreiber, H, Singh, S, Stauss, HJ   +5 more
core  

Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.

New England Journal of Medicine, 2011
BACKGROUND The multitargeted tyrosine kinase inhibitor sunitinib has shown activity against pancreatic neuroendocrine tumors in preclinical models and phase 1 and 2 trials.
E. Raymond, L. Dahan, J. Raoul, Y. Bang, I. Borbath, C. Lombard-Bohas, J. Valle, P. Metrakos, Denis Smith, A. Vinik, Jen‐Shi Chen, D. Hörsch, P. Hammel, B. Wiedenmann, E. Van Cutsem, S. Patyna, D. Lu, C. Blanckmeister, R. Chao, P. Ruszniewski   +19 more
semanticscholar   +1 more source

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Molecular Oncology, EarlyView.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee   +8 more
wiley   +1 more source

Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. [PDF]

, 2004
FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear.
Akagi, Tadaatsu, Hayashi, Kazuhiko, Jin, Gui-Shan, Kondo, Eisaku, Liu, Yi-Xuan, Miyake, Takayoshi, Shibata, Masao, Takashima, Takako, Yoshino, Tadashi   +8 more
core   +1 more source

World Health Organization classification of tumors

Cancer, 2000
World Health Organization Collaborating Centerfor International Histological Classification of Tu-mors, Armed Forces Institute of Pathology, Wash-ington, DC.Address for reprints: Leslie H.
P. Kleihues, L. Sobin
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Unsupervised Feature Selection for Tumor Profiles using Autoencoders and Kernel Methods [PDF]

arXiv, 2020
Molecular data from tumor profiles is high dimensional. Tumor profiles can be characterized by tens of thousands of gene expression features. Due to the size of the gene expression feature set machine learning methods are exposed to noisy variables and complexity. Tumor types present heterogeneity and can be subdivided in tumor subtypes.
arxiv  

Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

Molecular Oncology, EarlyView.
Ewing sarcoma is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF complex via ARID1A. ARID1A's ability to form biomolecular condensates is crucial for tumor growth, making it a potential therapeutic target. However, targeting these transient condensates is challenging, requiring further research. Ewing sarcoma,
Erich J. Sohn, David S. Libich
wiley   +1 more source

Renal papillary carcinoma developed in a kidney transplant recipient with late IgA-nephropathy [PDF]

, 2016
With improvements in immunosuppressive therapy, patient and graft survival in renal transplant recipients have been prolonged. Increasing donor age and patient survival rates have been related to an increase in the number of de novo tumors ...
BERLOCO, Pasquale Bartolomeo, G. Mennini, GIANNAKAKIS, Konstantinos, GUGLIELMO, NICOLA, MELANDRO, FABIO, NUDO, FRANCESCO, POLI, Luca, PRETAGOSTINI, Renzo   +7 more
core   +1 more source