Results 151 to 160 of about 6,547,471 (339)

Using somatic mutation data to test tumors for clonal relatedness

, 2015
A major challenge for cancer pathologists is to determine whether a new tumor in a patient with cancer is a metastasis or an independent occurrence of the disease.
Begg, Colin B., Ostrovnaya, Irina, Seshan, Venkatraman E.   +2 more
core   +1 more source

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

Acta Neuropathologica, 2016
D. Louis, A. Perry, G. Reifenberger, A. Deimling, D. Figarella-Branger, W. Cavenee, H. Ohgaki, O. Wiestler, P. Kleihues, D. Ellison   +9 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors [PDF]

, 2017
Victoria Stepanova, К. В. Дергилев, Kelci R. Holman, Yelena Parfyonova, З. И. Цоколаева, Mimi Teter, Elena N. Atochina‐Vasserman, Alla Volgina, С. В. Зайцев, Shane P. Lewis, Fedor Zabozlaev, Kseniya Obraztsova, Vera P. Krymskaya, Douglas B. Cines   +13 more
openalex   +1 more source

Liquid Biopsy’s Role in Head and Neck Tumors: Changing Paradigms in the Era of Precision Medicine

Diagnostics
In the era of precision medicine, liquid biopsy has become an indispensable tool in research and clinical diagnostics. This innovative molecular approach offers significant benefits in managing cancers, such as melanoma, colorectal cancer, lung cancer ...
Rudy N. Zalzal, Najla Fakhruddin, Rami Mahfouz   +2 more
doaj   +1 more source

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Science, 2017
D. Le, D. Le, J. Durham, J. Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Bjarne R. Bartlett, Laveet K. Aulakh, Laveet K. Aulakh, Steve Lu, Steve Lu, H. Kemberling, C. Wilt, Brandon S. Luber, F. Wong, F. Wong, N. Azad, A. Rucki, D. Laheru, R. Donehower, A. Zaheer, G. Fisher, T. Crocenzi, James J. Lee, T. Greten, A. Duffy, K. Ciombor, A. Eyring, B. Lam, A. Joe, S. Kang, M. Holdhoff, Ludmila V. Danilova, L. Cope, C. Meyer, Shibin Zhou, Shibin Zhou, R. Goldberg, D. Armstrong, K. Bever, A. Fader, J. Taube, F. Housseau, D. Spetzler, N. Xiao, D. Pardoll, N. Papadopoulos, N. Papadopoulos, K. Kinzler, K. Kinzler, J. Eshleman, B. Vogelstein, B. Vogelstein, R. Anders, R. Anders, L. Diaz, L. A. Diaz   +57 more
semanticscholar   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway

, 2022
Zexiao Jia, Shuxu Yang, Mengyao Li, Zhaoying Lei, Xue Ding, Mingjie Fan, Dixian Wang, Dajiang Xie, Hui Zhou, Yue Qiu, Qianqian Zhuang, Dan Li, Wei Yang, Xuchen Qi, Xiaohui Cang, Jingwei Zhao, Wenqi Wang, Aifu Lin, Qingfeng Yan   +18 more
openalex   +1 more source

Involvement of ACSM family genes in the reprogramming of lipid metabolism within tumors and their investigation as promising therapeutic targets

Frontiers in Cell and Developmental Biology
Metabolic reprogramming of tumor cells is an important feature of oncogenesis and progression, with lipid metabolism playing a key role in this process.
Ke-Xin Fang, Zi-Qi Li, Jin-Liang Dong, Ze Yu   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source