Results 71 to 80 of about 1,569,619 (249)

Natural Killer cells in non-hematopoietic malignancies

Frontiers in Immunology, 2012
Natural killer (NK) cells belong to the innate immune system and were initially described functionallywise by their spontaneous cytotoxic potential against transformed or virus-infected cells.
Mélanie eDesbois, Sylvie eRusakiewicz, Clara eLocher, laurence eZitvogel, Nathalie eChaput   +4 more
doaj   +1 more source

Tumor neoantigens and tumor immunotherapies

AGING MEDICINE
AbstractAs a high‐risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer.
Wang Jiani, Tan Qin, Ma Jie
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

Advanced Science
It is highly desired to achieve Type‐I photosensitizer (PS) to overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy‐atom‐free Type‐I PS T‐BNCy5 is presented by incorporating a biotin‐modified naphthalimide (NI) unit into
Guangxiao Yao, Junfeng Miao, Yingying Huo, Wei Guo   +3 more
doaj   +1 more source

NK Cell Exhaustion

Frontiers in Immunology, 2017
Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense.
Jiacheng Bi, Zhigang Tian, Zhigang Tian
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Involvement of ACSM family genes in the reprogramming of lipid metabolism within tumors and their investigation as promising therapeutic targets

Frontiers in Cell and Developmental Biology
Metabolic reprogramming of tumor cells is an important feature of oncogenesis and progression, with lipid metabolism playing a key role in this process.
Ke-Xin Fang, Zi-Qi Li, Jin-Liang Dong, Ze Yu   +3 more
doaj   +1 more source

Role of diffusion-weighted image in differentiation between epidermoid cyst and other cerebellopontine angle masses

Medical Journal of Babylon, 2018
Background: Many masses can present in the cerebellopontine angle (CPA), and the magnetic resonance imaging (MRI) is essential in the diagnosis and differential diagnosis of these masses, and a complimentary advanced MRI technique such as diffusion ...
Dhemyaa Ali Farhan, Osamah Ayad Abdulsttar   +1 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source