Results 41 to 50 of about 386,731 (264)
Journal de Ciencias Sociales, 2019 En este trabajo se aborda el concepto de internacionalización en el campo de la educación superior. La internacionalización se suele considerar como la respuesta transformadora del mundo académico ante la globalización (Beneitone, 2008).
María Juliana Laurito, Denise Benatuil
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Geophysical Research Letters, 2021 During the early to mid‐Holocene vegetation expanded to cover much of the present‐day Sahara. Although driven by a well‐understood difference in the orbital configuration, general circulation models have generally failed to simulate the required rainfall
Peter O. Hopcroft +2 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
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Tuning and Development of an Individual-Based Model of the Herring Spawning Migration
Frontiers in Marine Science, 2022 Norwegian spring spawning herring is a migratory pelagic fish stock that seasonally navigates between distant locations in the Norwegian Sea. The spawning migration takes place between late winter and early spring.
Cian Kelly +3 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Perspectives on Medical Education, 2013 Medical curricula, like healthcare systems and medical practice, have a strong cultural component and vary considerably between countries. Increasing mobility of medical graduates, and increasing pressure to ensure they are all fit for practice, have ...
Richard Marz +4 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Performance Optimal PI controller Tuning Based on Integrating Plus Time Delay Models
Algorithms, 2018 A method for tuning PI controller parameters, a prescribed maximum time delay error or a relative time delay error is presented. The method is based on integrator plus time delay models.
Christer Dalen, David Di Ruscio
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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