Results 51 to 60 of about 772,437 (297)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
God, Fine-Tuning, and the Problem of Old Evidence [PDF]
, 2004 The fundamental constants that are involved in the laws of physics which describe our universe are finely-tuned for life, in the sense that if some of the constants had slightly different values life could not exist.
Bradley Monton, Monton, Bradley
core
Development of simulation approach for CVT tuning using dual level genetic algorithm
Cogent Engineering, 2017 Presented work aims to develop Genetic Algorithm (GA) based simulation approach for tuning of Continuously Variable Transmission (CVT). This study uses force balance to model the behaviour of CVT in MATLAB and employs dual level GA to optimize the tuning
Deepinder Jot Singh Aulakh
doaj +1 more source
PD/PID controller tuning based on model approximations: Model reduction of some unstable and higher order nonlinear models [PDF]
Modeling, Identification and Control, 2017 A model reduction technique based on optimization theory is presented, where a possible higher order system/model is approximated with an unstable DIPTD model by using only step response data.
Christer Dalen, David Di Ruscio
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frequency domain iterative feedforward/feedback tuning for MIMO ANVC
, 2007 A new iterative feedback/feed-forward tuning (IFFT) method is presented for multiple-input multiple-output (MIMO) control systems that relies on efficient computation of the negative gradient of the controller cost function in the frequency domain.
Veres, S.M., Luo, J.
core +1 more source
Serum protein biomarkers for polymyalgia rheumatica: a case-control study
Frontiers in ImmunologyObjectivePolymyalgia rheumatica (PMR), a chronic inflammatory disease that affects older people, is characterized by musculoskeletal pain in the shoulder, neck, and pelvic girdle.
Hiroshi Furukawa +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Probability in Fine-Tuning Design Arguments [PDF]
, 2007 This paper examines probabilistic versions of the fine-tuning argument for design (FTA), with an emphasis on the interpretation of the probability statements involved in such arguments. Three categories of probability are considered: physical, epistemic,
Staley, Kent, Kent W. Staley
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source