Results 71 to 80 of about 1,595,436 (304)

Active Tuning

CoRR, 2020
We introduce Active Tuning, a novel paradigm for optimizing the internal dynamics of recurrent neural networks (RNNs) on the fly. In contrast to the conventional sequence-to-sequence mapping scheme, Active Tuning decouples the RNN's recurrent neural activities from the input stream, using the unfolding temporal gradient signal to tune the internal ...
Sebastian Otte, Matthias Karlbauer, Martin V. Butz   +2 more
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Gauging Fine-Tuning [PDF]

, 2018
We introduce a mathematical framework for quantifying fine-tuning in general physical settings. In particular, we identify two distinct perspectives on fine-tuning, namely, a local and a global perspective --- and develop corresponding measures.
Azhar, Feraz, Loeb, Abraham
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Self tuning scalar tensor black holes

, 2015
Studying a certain sub class of higher order Horndeski (scalar-tensor) theories we discuss a method discovered recently permitting analytic black hole solutions with a non trivial and regular scalar field.
Charmousis, Christos, Iosifidis, Damianos   +1 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tunable IDC Phase Shifter Based on Semiautomated Deposition of Graphene

IET Microwaves, Antennas & Propagation
In this work, a graphene‐based tunable phase shifter is proposed which deploys a semiautomated procedure for graphene deposition leading to a high‐quality graphene transfer.
Warda Saeed, Muhammad Yasir
doaj   +1 more source

Resonance tuning of two-photon absorption microcavities for wavelength-selective pulse monitoring [PDF]

, 2006
We show the potential use of a single photodetector for multichannel pulse monitoring. Two-photon absorption in a microcavity structure is used as the nonlinear optical technique for pulse monitoring. Angle tuning of the device allows the resonance to be
Barry, Liam P., Bradley, Ann Louise, Donegan, John Francis, Folliot, H., Guo, Wei Hua, Krug, T., Lynch, Michael, Maguire, Paul J., O'Dowd, John   +8 more
core   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source