Results 81 to 90 of about 1,512,342 (361)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Wide-bandwidth mode-hop-free tuning of extended-cavity GaN diode lasers
, 2005 We present a new approach for extended-cavity diode-laser tuning to achieve wide mode-hop-free tuning ranges. By using a multiple piezoactuated grating mount, the cavity length and grating angle in the laser can be adjusted independently, allowing mode ...
Burns, I.S., Kaminski, C.F., Hult, J.
core +1 more source
Data-driven control design for neuroprotheses: a virtual reference feedback tuning (VRFT) approach [PDF]
, 2004 This paper deals with design of feedback controllers for knee joint movement of paraplegics using functional electrical stimulation (FES) of the paralyzed quadriceps muscle group.
F. Previdi +15 more
core +1 more source
Performance Optimal PI controller Tuning Based on Integrating Plus Time Delay Models
Algorithms, 2018 A method for tuning PI controller parameters, a prescribed maximum time delay error or a relative time delay error is presented. The method is based on integrator plus time delay models.
Christer Dalen, David Di Ruscio
doaj +1 more source
Tuning and Development of an Individual-Based Model of the Herring Spawning Migration
Frontiers in Marine Science, 2022 Norwegian spring spawning herring is a migratory pelagic fish stock that seasonally navigates between distant locations in the Norwegian Sea. The spawning migration takes place between late winter and early spring.
Cian Kelly +3 more
doaj +1 more source
CoRR, 2020 We introduce Active Tuning, a novel paradigm for optimizing the internal dynamics of recurrent neural networks (RNNs) on the fly. In contrast to the conventional sequence-to-sequence mapping scheme, Active Tuning decouples the RNN's recurrent neural activities from the input stream, using the unfolding temporal gradient signal to tune the internal ...
Sebastian Otte +2 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Data-efficient Fine-tuning for LLM-based Recommendation [PDF]
Annual International ACM SIGIR Conference on Research and Development in Information RetrievalLeveraging Large Language Models (LLMs) for recommendation has recently garnered considerable attention, where fine-tuning plays a key role in LLMs' adaptation.
Xinyu Lin +6 more
semanticscholar +1 more source
Electro optical tuning of Tamm-plasmon exciton-polaritons
, 2014 This work was financially supported by the state of Bavaria, the bilateral project of the Deutsche Forschungsgemeinschaft (within the project LIEPOLATE) and the Polish Ministry of Science and higher education (Project No.
Gessler, J. +7 more
core +1 more source