Results 91 to 100 of about 772,437 (297)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A semi-automated design of instance-based fuzzy parameter tuning for metaheuristics based on decision tree induction [PDF]
, 2015 Two main concepts are established in the literature for the Parameter Setting Problem (PSP) of metaheuristics: Parameter Tuning Strategies (PTS) and Parameter Control Strategies (PCS).
Ries, Jana, Beullens, Patrick
core +1 more source
CarlosADuranVIllalobos/Tuning-Multivariable-Controller: v1.0.0
, 2022 Comparison of different tuning approaches for multivariable ...
CarlosADuranVIllalobos
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Tuning template for radiography in Europe [PDF]
The following document is the Tuning Template for Radiography Education in Europe. Radiography is one of the Socrates Thematic Networks which will incorporate Tuning methodology. The Higher Education Network for Radiography in Europe (HENRE Network) will
Harris, Phil +7 more
core
Adaptive Transcutaneous Power Transfer to Implantable Devices: A State of the Art Review
Sensors, 2016 Wireless energy transfer is a broad research area that has recently become applicable to implantable medical devices. Wireless powering of and communication with implanted devices is possible through wireless transcutaneous energy transfer.
Kara N. Bocan, Ervin Sejdić
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Split-cavity tuning of a rectangular axion haloscope operating around 8.4 GHz
Frontiers in PhysicsThe axion haloscope is the currently most sensitive method to probe the vanishingly small coupling of this prominent Dark Matter candidate to photons. To scan a sizeable axion Dark Matter parameter space, the cavities that make up the haloscope need to ...
Jessica Golm +6 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source