Results 121 to 130 of about 296,058 (324)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Turbo-Detected Unequal Protection MPEG-4 Audio Transceiver Using Convolutional Codes, Trellis Coded Modulation and Space-Time Trellis Coding

, 2005
A jointly optimised turbo transceiver capable of providing unequal error protection is proposed for employment in an MPEG-4 aided audio transceiver. The transceiver advocated consists of Space-Time Trellis Coding (STTC), Trellis Coded Modulation (TCM ...
Hanzo, L., Ng, S.X., Othman, N.S.
core  

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes

ChemBioChem, EarlyView.
Group II Introns (G2Is) are large self‐splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2, an unexpectedly proficient ribozyme, self‐splices not only in vitro, but also in Escherichia coli cells.
Deni Szokoli, Noemi E. Nwosu, Lukas M. Glatt, Hannes Mutschler   +3 more
wiley   +1 more source

A MODIFIED UNEQUAL POWER ALLOCATION (UPA) SCHEME FOR PERFORMANCE ENHANCEMENT IN BIT REPETITION TURBO CODES IN HIGH SPEED DOWNLINK PACKET ACCESS (HSDPA) SYSTEM [PDF]

Journal of Engineering Science and Technology, 2015
In this paper, a modified optimal power allocation scheme for different bits in turbo encoder has been proposed to improve the performance of Turbo Codes system in High Speed Downlink Packet Access (HSDPA) service. In a typical turbo code in HSDPA system,
B. BALAMURALITHARA
doaj  

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

Discussion: “Solar Turbo Power Plant Design” (Mackay, D. B., and Leventhal, E. L., 1960, ASME J. Eng. Power, 82, pp. 315–323) [PDF]

, 1960
C. L. Walker, Yuanchen Tang
openalex   +1 more source

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang, Mike Preigh, Jing Wang, Eleni Venetsanakos, Yujin Wang, Elly Barry, Don Corson   +6 more
wiley   +1 more source

Haberleşme Sistemlerinde Turbo Kodlama ve Turbo İlkesinin Bazı Pratik Uygulamaları

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2013
söz etmiştir. Shannon, veri iletim hızı içi teorik bir sınır tanımlamış ve Shannon’dan günümüze kadar bu sınıra yaklaşma çabaları sürmüştür. Shannon’dan sonra çok sayıda etkin kodlama ve kod çözme teknikleri bulunmuş olmasına rağmen, 90’lı yılların ...
Selman KULAÇ, Murat Hüsnü SAZLI
doaj   +2 more sources

Spin‐Crossover in a Dinuclear Iron(II) Complex on Highly Oriented Pyrolytic Graphite: An X‐Ray Absorption Spectroscopy Study

ChemPhysChem, EarlyView.
This study investigates a spin‐crossover dinuclear Fe(II) complex deposited as a thin film under ultrahigh‐vacuum conditions by a pulsed layer injection technique. Its temperature‐dependent switching behavior, light‐induced excited spin‐state trapping, soft‐X‐ray‐induced excited spin‐state trapping, and temperature‐ and light‐induced spin crossover ...
Marcel Walter, Sebastien Elie Hadjadj, Clara Trommer, Jorge Torres, Jendrik Gördes, David Swerev, Tauqir Shinwari, Christian Lotze, Chen Luo, Florin Radu, Felix Tuczek, Sangeeta Thakur, Wolfgang Kuch   +12 more
wiley   +1 more source

Predicting Maternal and Fetal Exposures of Elexacaftor–Tezacaftor–Ivacaftor during Pregnancy through Physiologically Based Pharmacokinetic Models

Clinical Pharmacology &Therapeutics, EarlyView.
The use of elexacaftor/tezacaftor/ivacaftor (ETI) has been associated with increased fertility in women with cystic fibrosis (CF) and is increasingly used during pregnancy to support both maternal and fetal health. However, little is known about the pharmacokinetics (PK) of ETI during pregnancy, which is crucial for optimizing its efficacy and safety ...
Eunjin Hong, Mary F. Hebert, Emily Fay, Grant Turner, Patricia Eshaghian, Aaron Trimble, Peter S. Chung, Adupa P. Rao, Paul M. Beringer   +8 more
wiley   +1 more source