Results 91 to 100 of about 8,459 (175)

Effective faking of verbal deception detection with target‐aligned adversarial attacks

Legal and Criminological Psychology, EarlyView.
Abstract Background Deception detection through analysing language is a promising avenue using both human judgements and automated machine learning judgements. For both forms of credibility assessment, automated adversarial attacks that rewrite deceptive statements to appear truthful pose a serious threat.
Bennett Kleinberg, Riccardo Loconte, Bruno Verschuere   +2 more
wiley   +1 more source

PLP Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in Salmonella enterica

Molecular Microbiology, EarlyView.
Cellular pool of aromatic amino acid aminotransferase proteins represented as holo‐ or apo‐ enzymes, reflecting presence or absence of associated PLP. Status of PLPHP is implicated in determining the ratio of holo‐ and apo‐TyrB. ABSTRACT Pyridoxal 5′‐phosphate (PLP) is an essential cofactor required for metabolic functions including amino acid ...
Brandi A. Buckner, Diana M. Downs
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Impact of recurrent dehydration with mild periodic water restriction on blood pressure and renal function in male spontaneously hypertensive rats

Experimental Physiology, EarlyView.
Abstract The kidneys regulate fluid balance but are susceptible to adverse effects of inadequate hydration. Epidemiological studies have linked low water intake to renal dysfunction and chronic kidney disease. Previously we showed that restricting water intake to a single 2‐h period daily for 4 weeks promotes hypertension as well as renal inflammation,
Katrina M. Mirabito Colafella, Peter N. H. Nguyen, Zoe McArdle, Debra Fong, Edmund Kwok, Kate M. Denton, Antony Vinh, Lucinda M. Hilliard Krause   +7 more
wiley   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

On Not Being Stuck: Changing Humanities in 20th‐ and 21st‐Century Britain: The Lorna Sage Lecture, 2025

Critical Quarterly, EarlyView.
Helen Small
wiley   +1 more source

Small Language Models: A Systematic Review of Computational Trade‐Offs, Privacy Advantages and Deployment in Intelligent Systems

Expert Systems, Volume 43, Issue 8, August 2026.
ABSTRACT This systematic review synthesizes evidence from 68 studies, including peer‐reviewed journal articles, indexed conference/workshop proceedings and five remaining arXiv preprints published between 2022 and 2025, on small language models (SLMs) as computationally efficient alternatives to large language models (LLMs).
Sena Dikici, Turgay Tugay Bilgin
wiley   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2183-2192, July 2026.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Bandwidth-efficient and reliable communication in smart grid systems for modern energy networks using Trellis and Turbo Trellis Coded Modulation. [PDF]

Sci Rep
Ghallab R, Shaheen M, Elkorany AS, El-Feshawy SA.   +3 more
europepmc   +1 more source

Unraveling the Bioactive Compounds and Multi‐Target Mechanisms of the Fructus Aurantii Immaturus‐Bambusae Caulis in Taeniam Herb Pair Against Chronic Gastritis: Integrating Identification of Absorbed Constituents, Targeted Network Pharmacology, and Computational Validation

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This work systematically explored the anti‐chronic gastritis mechanism of the FAI‐BCT herb pair. UPLC‐Q‐TOF‐MS/MS was applied to identify absorbed prototypes and metabolites of FAI‐BCT in rat plasma. Combining database mining, network pharmacology, molecular docking, and molecular dynamics simulation, we screened the key bioactive components and core ...
Yinghua Ma, Weiwei Xie, Jing Song, Yabin Qin, Yile Zhao   +4 more
wiley   +1 more source