Results 101 to 110 of about 57,448 (230)

Pharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants With Obesity or Overweight

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the bioequivalence of orally administered orforglipron tablets and capsules in participants with obesity or overweight who were otherwise healthy. Materials and Methods This phase 1, multicenter, open‐label, multiple‐dose, dose‐escalation study was conducted in 429 healthy adults.
Xiaosu Ma, Ying Grace Li, Sohini Raha, David C. Sperry, David E. Coutant, Shobha Bhattachar   +5 more
wiley   +1 more source

Diffusion tensor imaging in anterior interosseous nerve syndrome – functional MR Neurography on a fascicular level

NeuroImage: Clinical, 2019
Purpose: By applying diffusor tensor imaging (DTI) in patients with anterior interosseous nerve syndrome (AINS), this proof of principle study aims to quantify the extent of structural damage of a peripheral nerve at the anatomical level of individual ...
Tim Godel, Mirko Pham, Henrich Kele, Moritz Kronlage, Daniel Schwarz, Merle Brunée, Sabine Heiland, Martin Bendszus, Philipp Bäumer   +8 more
doaj   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Patents and Supra‐Competitive Prices: Evidence From Consumer Products

Journal of Empirical Legal Studies, EarlyView.
ABSTRACT A patent system is a central tool in innovation policy. The prospect of monopolistic pricing supposedly encourages firms to innovate. However, there is scant empirical evidence supporting the existence of higher markups for patent‐protected products.
Gaétan de Rassenfosse, Ling Zhou
wiley   +1 more source

New principle of organization of working process of air conditioning systems at railway and sea transport [PDF]

Transport Problems, 2008
An indispensable component of ensuring safe control of railway and sea transport in conditions of hot climate is maintenance of comfortable temperature of air in control cabins and living spaces.
Andrey KRAJNIUK, Aleksander KRAJNIUK
doaj  

Conducting Medication Reviews: A Comparative Study Between ChatGPT‐4 and Healthcare Professionals

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The increasing prevalence of patients with hyperpolypharmacy (> 10 medications) has made medication reviews increasingly complex. ChatGPT‐4‐Turbo (ChatGPT), a large language model, has demonstrated potential in healthcare applications and could potentially support medication reviews.
Simone M. K. ten Hoope, Sabrina Marongiu, Carl E. H. Siegert, Eibert R. Heerdink, Marjo J. A. Janssen, Fatma Karapinar‐Çarkit   +5 more
wiley   +1 more source

Inter-carrier interference mitigation for underwater acoustic communications [PDF]

Communicating at a high data rate through the ocean is challenging. Such communications must be acoustic in order to travel long distances. The underwater acoustic channel has a long delay spread, which makes orthogonal frequency division multiplexing ...
Daly, Erica Lynn
core  

Developing and Evaluating the Use of ChatGPT as a Screening Tool for Nurses Conducting Structured Literature Reviews: Proof of Concept Study Results

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To examine the feasibility of using a large language model (LLM) as a screening tool during structured literature reviews to facilitate evidence‐based practice. Design A proof‐of‐concept study. Methods This paper outlines an innovative method of abstract screening using ChatGPT and computer coding for large scale, effective and efficient ...
Alexandra Mudd, Tiffany Conroy, Siri Lygum Voldbjerg, Anita Goldschmied, Rebecca Feo, Lambert Schuwirth   +5 more
wiley   +1 more source