Results 101 to 110 of about 8,459 (175)

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru   +7 more
wiley   +1 more source

In Situ pH Determination Using 1H‐MRS Acetate Chemical Shift for Noninvasive Postmortem Examinations

open access: yesNMR in Biomedicine, Volume 39, Issue 7, July 2026.
The chemical‐shift difference between acetate and myo‐inositol measured by MRS enables estimation of pH in the acidic range. Noninvasive pH assessment in forensic investigations is demonstrated in 58 cases and validated by measurements in extracted tissue.
Sabina Frese   +4 more
wiley   +1 more source

AI agents are sensitive to nudges. [PDF]

open access: yesProc Natl Acad Sci U S A
Cherep M, Maes P, Singh N.
europepmc   +1 more source

Dipolar Order Mapping Based on Spin‐Lock Magnetic Resonance Imaging

open access: yesNMR in Biomedicine, Volume 39, Issue 7, July 2026.
To quantify the dipolar order relaxation time T1D$$ {T}_{1D} $$ using spin‐lock MRI technique, we introduce a T1D$$ {T}_{1D} $$‐specific ratio, denoted as RATIOdosl$$ {RATIO}_{dosl} $$. A novel rotary‐echo spin‐lock sequence was developed to enable dual‐frequency spin‐lock acquisition.
Zijian Gao   +4 more
wiley   +1 more source

A Phase 1, Open‐Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy Participants

open access: yesClinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT This was a Phase 1, open label, randomized, crossover study to evaluate the safety and pharmacokinetics of multiple doses of intranasal naloxone (NCT05377255). Twenty‐four healthy participants were enrolled at a single site in the US to one of two sequences.
David Cassie   +4 more
wiley   +1 more source

Pharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants With Obesity or Overweight

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5803-5809, July 2026.
ABSTRACT Aims To evaluate the bioequivalence of orally administered orforglipron tablets and capsules in participants with obesity or overweight who were otherwise healthy. Materials and Methods This phase 1, multicenter, open‐label, multiple‐dose, dose‐escalation study was conducted in 429 healthy adults.
Xiaosu Ma   +5 more
wiley   +1 more source

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