Results 121 to 130 of about 1,541,181 (239)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

AI agents are sensitive to nudges. [PDF]

Proc Natl Acad Sci U S A
Cherep M, Maes P, Singh N.
europepmc   +1 more source

TURBO: The Swiss Knife of Auto-Encoders. [PDF]

Entropy (Basel), 2023
Quétant G, Belousov Y, Kinakh V, Voloshynovskiy S.   +3 more
europepmc   +1 more source

Hybrid‐Electric Aeroengines: Strategic Technical Pathways and Environmental Implications

Advanced Energy and Sustainability Research, Volume 7, Issue 8, August 2026.
Hybrid‐electric propulsion systems represent a transformative frontier in aerospace engineering, critical for achieving sustainable aviation. This review synthesizes recent breakthroughs in hybrid‐energy aero‐engine design, critically evaluating key technological pillars.
Yankun Wang, Mingkui Wang
wiley   +1 more source

Two-fraction Ultrahypofractionated Radiotherapy with focal BOost for intermediate-risk, localized prostate cancer (TURBO): study protocol of a phase II, randomized controlled clinical trial. [PDF]

Trials
Lalmahomed TA, Monninkhof EM, van Rijssel MJ, van Melick HHE, Verkooijen HM, de Boer JCJ, van der Voort van Zyp JRN.   +6 more
europepmc   +1 more source

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Animal models demonstrated that pharmacologically‐induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer's disease (AD) pathology and cognitive deficits.
Prokopis C. Prokopiou, Maxime Van Egroo, Joost M. Riphagen, Marion Baillet, Nicholas J. Ashton, Shorena Janelidze, Reisa A. Sperling, Keith A. Johnson, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs   +11 more
wiley   +1 more source

Breaking barriers: harnessing artificial intelligence for a stigma-free, efficient HIV prevention assessment among adults in South Africa. [PDF]

Front Digit Health
Govathson C, Chetty-Makkan C, Greener R, Frade S, Rech D, Morris S, Richard Y, Mendonca R, Maricich N, Long L, Pascoe S.   +10 more
europepmc   +1 more source

Anterior Cruciate Ligament Reconstruction and Medial Collateral Ligament Augmentation With Pedicled Gracilis Tendon to Address Anteromedial Rotatory and Valgus Instability

Arthroscopy Techniques, Volume 15, Issue 8, August 2026.
Abstract Combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries with persistent grade II valgus (Fetto/Marshall classification) or anteromedial rotatory instability pose a significant risk to ACL graft integrity if treated in isolation.
Lukas Willinger, Julian Mehl, Sebastian Siebenlist, Armin Runer   +3 more
wiley   +1 more source

Challenges of using generative AI for patient education in chronic heart failure: an evaluation of content quality, readability, and actionability in cross-platform LLM-generated texts. [PDF]

Front Public Health
Wang Z, Li X, Ma C, Zhang Z.
europepmc   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2885-2898, August 2026.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source