Results 31 to 40 of about 10,368 (265)

Assessment of Different Boundary Layer Parameterization Schemes in Numerical Simulations of Typhoon Nida (2016) Based on Aircraft Observations

Atmosphere, 2023
This study aimed to find a boundary layer parameter scheme suitable for typhoons in the South China Sea based on a comparison with the aircraft detection data from Typhoon Nida (2016).
Chaoyong Tu, Zhongkuo Zhao, Mingsen Zhou, Weibiao Li, Min Xie, Changjiang Ni, Shumin Chen   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Submesoscales are a significant turbulence source in global ocean surface boundary layer

Nature Communications
The turbulent ocean surface boundary layer is a key part of the climate system affecting both the energy and carbon cycles. Accurately simulating the boundary layer is critical in improving climate model performance, which deeply relies on our ...
Jihai Dong, Baylor Fox-Kemper, Jacob O. Wenegrat, Abigail S. Bodner, Xiaolong Yu, Stephen Belcher, Changming Dong   +6 more
doaj   +1 more source

The Influence of Laminarizers on the Turbulent Boundary Layer and Prediction of Effective Flow Conditions around Surfaces [PDF]

Problems of the Regional Energetics
The development of effective methods for boundary layer laminarization is a fundamental task for the efficient and reliable operation of power equipment.
Chukalin A.V., Kovalnogov V.N., Sherkunov V.V., Savelov O.V.   +3 more
doaj   +1 more source

A Coordinate Transformation for Unsteady Boundary Layer Equations [PDF]

INCAS Bulletin, 2011
This paper presents a new coordinate transformation for unsteady, incompressible boundary layer equations that applies to both laminar and turbulent flows. A generalization of this coordinate transformation is also proposed.
Paul G. A. CIZMAS
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Visualization Experiment of Velocity Boundary Layer in Rectangular Channel Using PIV Technique

Yuanzineng kexue jishu, 2023
The plate-type fuel has compact structure and narrow coolant channel. The size effect of large aspect ratio makes the narrow rectangular channel have certain heat transfer enhancement effect, and can meet the requirements of miniaturization, high power ...
ZHANG Yonghao;YU Xiaoyong;LIU Luguo;QIAO Shouxu;TAN Sichao
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source