Results 41 to 50 of about 204,183 (308)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Submesoscales are a significant turbulence source in global ocean surface boundary layer

Nature Communications
The turbulent ocean surface boundary layer is a key part of the climate system affecting both the energy and carbon cycles. Accurately simulating the boundary layer is critical in improving climate model performance, which deeply relies on our ...
Jihai Dong, Baylor Fox-Kemper, Jacob O. Wenegrat, Abigail S. Bodner, Xiaolong Yu, Stephen Belcher, Changming Dong   +6 more
doaj   +1 more source

A Coordinate Transformation for Unsteady Boundary Layer Equations [PDF]

INCAS Bulletin, 2011
This paper presents a new coordinate transformation for unsteady, incompressible boundary layer equations that applies to both laminar and turbulent flows. A generalization of this coordinate transformation is also proposed.
Paul G. A. CIZMAS
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Visualization Experiment of Velocity Boundary Layer in Rectangular Channel Using PIV Technique

Yuanzineng kexue jishu, 2023
The plate-type fuel has compact structure and narrow coolant channel. The size effect of large aspect ratio makes the narrow rectangular channel have certain heat transfer enhancement effect, and can meet the requirements of miniaturization, high power ...
ZHANG Yonghao;YU Xiaoyong;LIU Luguo;QIAO Shouxu;TAN Sichao
doaj  

Sonic Eddy Model of the Turbulent Boundary Layer

Fluids, 2022
The effects of Mach number on the skin friction and velocity fluctuations of the turbulent boundary layer are considered through a sonic eddy model. Originally proposed for free shear flows, the model assumes that the eddies responsible for momentum ...
Paul Dintilhac, Robert Breidenthal
doaj   +1 more source

Analytic Model of the Universal Structure of Turbulent Boundary Layers

, 2006
Turbulent boundary layers exhibit a universal structure which nevertheless is rather complex, being composed of a viscous sub-layer, a buffer zone, and a turbulent log-law region.
L'vov, Victor S., Procaccia, Itamar, Rudenko, Oleksii   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source