Results 41 to 50 of about 10,368 (265)

Turbulent Kinetic Energy Production in the Vane of a Low-Pressure Linear Turbine Cascade with Incoming Wakes

open access: yesInternational Journal of Rotating Machinery, 2015
Incompressible large eddy simulation and direct numerical simulation of a low-pressure turbine at Re=5.18×104 and 1.48×105 with discrete incoming wakes are analyzed to identify the turbulent kinetic energy generation mechanism outside of the blade ...
V. Michelassi, J. G. Wissink
doaj   +1 more source

Boundary-layer turbulence as a kangaroo process [PDF]

open access: yesPhysical Review E, 1995
A nonlocal mixing-length theory of turbulence transport by finite size eddies is developed by means of a novel evaluation of the Reynolds stress. The analysis involves the contruct of a sample path space and a stochastic closure hypothesis. The simplifying property of exhange (strong eddies) is satisfied by an analytical sampling rate model.
Dekker, H.   +2 more
openaire   +5 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Sonic Eddy Model of the Turbulent Boundary Layer

open access: yesFluids, 2022
The effects of Mach number on the skin friction and velocity fluctuations of the turbulent boundary layer are considered through a sonic eddy model. Originally proposed for free shear flows, the model assumes that the eddies responsible for momentum ...
Paul Dintilhac, Robert Breidenthal
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Amplitude modulated near-wall cycle in a turbulent boundary layer under an adverse pressure gradient

open access: yesArchives of Mechanics, 2013
This paper presents the effect of amplitude modulation of small-scale turbulence by large-scale structures in a turbulent boundary layer subjected to an adverse pressure gradient.
A. Dróżdż, W. Elsner
doaj   +1 more source

Transitional–turbulent spots and turbulent–turbulent spots in boundary layers [PDF]

open access: yesProceedings of the National Academy of Sciences, 2017
Significance Uncovering the constitutive coherent structure in the inner layer of the canonical turbulent boundary layer has remained a central fluid mechanics theme, because it tests our intellectual ability to understand even the simplest external flow.
Xiaohua, Wu   +5 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

DNS Study of Effects of Suddenly-Vanishing Wall Heating in Turbulent Boundary Layer

open access: yesJournal of Thermal Science and Technology, 2012
The objective of this study is to investigate a thermal field in the turbulent boundary layer by means of direct numerical simulation (DNS), in which the wall heating has suddenly vanished in the downstream region, i.e., the wall is heated by a constant ...
Hirofumi HATTORI   +2 more
doaj   +1 more source

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