Results 41 to 50 of about 34,613 (317)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Measurements in an urban-type boundary layer. [PDF]

, 2008
Wind tunnel measurements of the boundary layer flow over a very rough surface comprising a staggered array of cubes are presented and discussed. Attention is concentrated on the near-wall region, including the canopy region below the tops of the ...
Ian P. Castro, Reynolds, Ryan T., Ryan T. Reynolds, Castro, Ian P.   +3 more
core   +1 more source

An experimental study on the equilibrium boundary layer subjected to favourable pressure gradient (Effect of pressure gradient on law of the wall)

Nihon Kikai Gakkai ronbunshu, 2021
Effect of favorable pressure gradient on the wall similarity in turbulent boundary layer has been investigated experimentally. An appropriately adjusted pressure gradient produces an equilibrium boundary layer of which momentum thickness Reynolds number ...
Yudai HIKITA, Hiroki SUZUKI, Takatsugu KAMEDA, Shinsuke MOCHIZUKI   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Influence of Laminarizers on the Turbulent Boundary Layer and Prediction of Effective Flow Conditions around Surfaces [PDF]

Problems of the Regional Energetics
The development of effective methods for boundary layer laminarization is a fundamental task for the efficient and reliable operation of power equipment.
Chukalin A.V., Kovalnogov V.N., Sherkunov V.V., Savelov O.V.   +3 more
doaj   +1 more source

A Coordinate Transformation for Unsteady Boundary Layer Equations [PDF]

INCAS Bulletin, 2011
This paper presents a new coordinate transformation for unsteady, incompressible boundary layer equations that applies to both laminar and turbulent flows. A generalization of this coordinate transformation is also proposed.
Paul G. A. CIZMAS
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Direct numerical simulation of 'short' laminar separation bubbles with turbulent reattachment [PDF]

, 2000
Direct numerical simulation of the incompressible Navier–Stokes equations is used to study flows where laminar boundary-layer separation is followed by turbulent reattachment forming a closed region known as a laminar separation bubble.
Alam, M., Sandham, N.D.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source