Results 61 to 70 of about 10,368 (265)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The impact of three-dimensional compression on supersonic boundary layers [PDF]

AIP Advances
By using vertically intersecting double wedges, the effect of three-dimensional compression on a supersonic boundary layer transition and turbulent characteristics is experimentally investigated by means of nanoparticle-based planar laser scattering and ...
Qiancheng Wang, Jinghao Wen, Yuxin Zhao, Yilong Zhao   +3 more
doaj   +1 more source

Remarks on the Equilibrium Turbulent Boundary Layer [PDF]

Journal of the Aeronautical Sciences, 1957
Two similarity laws are known for the mean-velocity profile in a turbulent boundary layer with constant pressure. These are Prandtl's law of the wall and Karman's momentum-defect law. The first law has recently been generalized empirically to flows with arbitrary pressure gradient by Ludwieg and Tillmann, and the second law to a certain class of ...
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Particles turbulence interactions in boundary layers [PDF]

ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, 2005
AbstractTurbulent dispersed flows in boundary layers are crucial in a number of industrial and environmental applications. In most applications, the key information is space distribution of particles which is known to be strongly non‐homogeneous. Specifically, inertial particles distribute preferentially avoiding strong vortical regions and segregating
openaire   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Interaction Layer Between a Turbulent Boundary Layer and Free-Stream Turbulence [PDF]

, 2016
The interaction between a turbulent free-stream and a turbulent boundary layer is investigated through particle image velocimetry measurements. An ‘interaction layer’ located between \(0.12 \le y/\delta \le 0.19\), at the end of the log layer, is identified whereby the kinetic energy in this layer describes the flow above it. Conditional averages about
Hearst, Jason, Dogan, Eda, Ganapathisubramani, Bharath   +2 more
openaire   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A Cloud Top Radiative Cooling Model Coupled With CLUBB in the Community Atmosphere Model: Description and Simulation of Low Clouds

Journal of Advances in Modeling Earth Systems, 2019
In this study, a higher‐order closure scheme known as Cloud Layers Unified By Binormals (CLUBB) is coupled with a cloud top radiative cooling scheme (RAD).
Zhun Guo, Minghuai Wang, Vincent E. Larson, Tianjun Zhou   +3 more
doaj   +1 more source