Results 61 to 70 of about 204,183 (308)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Moist turbulent Rayleigh-Benard convection with Neumann and Dirichlet boundary conditions

, 2012
Turbulent Rayleigh-Benard convection with phase changes in an extended layer between two parallel impermeable planes is studied by means of three-dimensional direct numerical simulations for Rayleigh numbers between 10^4 and 1.5\times 10^7 and for ...
Emanuel K. A., Fiedler B. H., Jörg Schumacher, Thomas Weidauer, Wyngaard J. C.   +4 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Boundary layers and turbulence

Physical Oceanography, 1999
We analyze the results of investigation of turbulent boundary layers typical of geophysical objects. It is shown that boundary layers of various nature are self-regulating sustems characterized by relatively slow evolutionary processes of formation accompanied by the growth of instabilities of different types and then replaced by the rapid development ...
E. P. Anisimova, A. A. Speranskaya
openaire   +1 more source

Direct numerical simulation of 'short' laminar separation bubbles with turbulent reattachment

, 2000
Direct numerical simulation of the incompressible Navier–Stokes equations is used to study flows where laminar boundary-layer separation is followed by turbulent reattachment forming a closed region known as a laminar separation bubble.
Alam, M., Sandham, N.D.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The impact of three-dimensional compression on supersonic boundary layers [PDF]

AIP Advances
By using vertically intersecting double wedges, the effect of three-dimensional compression on a supersonic boundary layer transition and turbulent characteristics is experimentally investigated by means of nanoparticle-based planar laser scattering and ...
Qiancheng Wang, Jinghao Wen, Yuxin Zhao, Yilong Zhao   +3 more
doaj   +1 more source

On optical imaging through aircraft turbulent boundary layers [PDF]

, 1980
Optical resolution quality as affected by aircraft turbulent boundary layers is analyzed. Wind-tunnel data was analyzed to obtained the variation of boundary layer turbulence scale length and mass density rms fluctuations with Mach number.
Sutton, G. W.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source