Results 61 to 70 of about 34,613 (317)

Nonlinear control of unsteady finite-amplitude perturbations in the Blasius boundary-layer flow [PDF]

, 2013
The present work provides an optimal control strategy, based on the nonlinear Navier–Stokes equations, aimed at hampering the rapid growth of unsteady finite-amplitude perturbations in a Blasius boundary-layer flow.
DE PALMA, Pietro, CHERUBINI, Stefania, ROBINET, Jean-Christophe   +2 more
core   +1 more source

DNS Study of Effects of Suddenly-Vanishing Wall Heating in Turbulent Boundary Layer

Journal of Thermal Science and Technology, 2012
The objective of this study is to investigate a thermal field in the turbulent boundary layer by means of direct numerical simulation (DNS), in which the wall heating has suddenly vanished in the downstream region, i.e., the wall is heated by a constant ...
Hirofumi HATTORI, Syohei YAMADA, Tomoya HOURA   +2 more
doaj   +1 more source

Transitional–turbulent spots and turbulent–turbulent spots in boundary layers [PDF]

Proceedings of the National Academy of Sciences, 2017
SignificanceUncovering the constitutive coherent structure in the inner layer of the canonical turbulent boundary layer has remained a central fluid mechanics theme, because it tests our intellectual ability to understand even the simplest external flow.
Xiaohua, Wu, Parviz, Moin, James M, Wallace, Jinhie, Skarda, Adrián, Lozano-Durán, Jean-Pierre, Hickey   +5 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

DNS and modeling of the turbulent boundary layer over an evaporating liquid film [PDF]

, 2009
In this paper, Direct Numercial Simulation (DNS) is used to study the boundary layer above an evaporating liquid film in the fully developed turbulent channel flow configuration.
Cuenot, Bénédicte, Chawki Habchi, Thierry Poinsot, Gaëtan Desoutter, Bénédicte Cuenot, Desoutter, Gaëtan, Habchi, Chawki, Poinsot, Thierry   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Amplitude modulated near-wall cycle in a turbulent boundary layer under an adverse pressure gradient

Archives of Mechanics, 2013
This paper presents the effect of amplitude modulation of small-scale turbulence by large-scale structures in a turbulent boundary layer subjected to an adverse pressure gradient.
A. Dróżdż, W. Elsner
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

RANS Modeling of Stably Stratified Turbulent Boundary Layer Flows in OpenFOAM®

E3S Web of Conferences, 2015
Quantifying mixing processes relating to the transport of heat, momentum, and scalar quantities of stably stratified turbulent geophysical flows remains a substantial task. In a stably stratified flow, such as the stable atmospheric boundary layer (SABL),
Wilson Jordan M., Venayagamoorthy Subhas K.   +1 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source